Rh-Catalyzed Highly Enantioselective Hydroalkynylation Reaction of Norbornadiene Derivatives

被引：40

作者：

Fan, Baomin ^{[1
]}

Xu, Jianbin ^{[1
]}

Yang, Qingjing ^{[1
]}

Li, Sifeng ^{[1
]}

Chen, Hualei ^{[1
]}

Liu, Shanshan ^{[1
]}

Yu, Lu ^{[1
]}

Zhou, Yongyun ^{[1
]}

Wang, Lin ^{[1
]}

机构：

[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 23期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING REACTIONS; ASYMMETRIC ADDITION; OXABICYCLIC ALKENES; 2+2 CYCLOADDITION; TERMINAL ALKYNES; COMPLEX;

D O I：

10.1021/ol402804t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The complexes of various Rh precusors with ferrocenyl chiral ligand (R,S)-Cy2PF-PPh2 were found effective catalysts for the asymmetric hydroalkynylation reaction of norbornadiene derivatives. When RhCl3 center dot 3H(2)O was employed, good yields (up to 98%) and high enantioselectivities (up to >99.9% ee) could be obtained for the reactions of a broad scope of substrates.

引用

页码：5956 / 5959

页数：4

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