Asymmetric Michael-Aldol Tandem Reaction of 2-Substituted Benzofuran-3-ones and Enones: A Facile Synthesis of Griseofulvin Analogues

被引：44

作者：

Dong, Nan ^{[1
]}

Li, Xin ^{[1
]}

Wang, Feng ^{[1
]}

Cheng, Jin-Pei ^{[1
]}

机构：

[1] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 18期

基金：

中国国家自然科学基金;

关键词：

3-SUBSTITUTED BENZOFURAN-2(3H)-ONES; CHEMICAL STRUCTURE; ADDITION-REACTIONS; DL-GRISEOFULVIN; ORAL TREATMENT; ANTIBIOTICS; DERIVATIVES; RINGWORM;

D O I：

10.1021/ol402346c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective Michael aldol tandem reaction with respect to prochiral 2-substituted benzofuran-3-ones and enones by a facile primary amine catalyst was investigated. The approach provides rapid access to the desired pharmaceutically active griseofulvin analogues.

引用

页码：4896 / 4899

页数：4

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