Trending Topics on Coumarin and Its Derivatives in 2020

被引：96
作者：
Carneiro, Aitor [1 ]
Matos, Maria Joao [1 ,2 ]
Uriarte, Eugenio [1 ,3 ]
Santana, Lourdes [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, Santiago De Compostela 15782, Spain
[2] Univ Porto, Fac Sci, Dept Chem & Biochem, CIQUP, Rua Campo Alegre 687, P-4169007 Porto, Portugal
[3] Univ Autonoma Chile, Inst Ciencias Quim Aplicadas, Santiago 7500912, Chile
来源：
MOLECULES | 2021年 / 26卷 / 02期
关键词：
coumarins; biological applications; drug discovery; fluorescent probes;
D O I：
10.3390/molecules26020501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many research articles and reviews compile information on this important family of compounds. In this overview, the most recent research papers and reviews from 2020 are organized and analyzed, and a discussion on these data is included. Multiple electronic databases were scanned, including SciFinder, Mendeley, and PubMed, the latter being the main source of information. Particular attention was paid to the potential of coumarins as an important scaffold in drug design, as well as fluorescent probes for decaging of prodrugs, metal detection, and diagnostic purposes. Herein we do an analysis of the trending topics related to coumarin and its derivatives in the broad field of drug discovery.
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页数：15
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