SYNTHESIS AND ANTHELMINTIC ACTIVITY OF TRIHETEROCYCLES: [5′-(5"-SUBSTITUTED-3"-PHENYLINDOL-2′-YL)-1′,3′,4′-OXADIAZOL-2′-YL-THIOMETHYL] BENZIMIDAZOLES

被引：0

作者：

Manjunath, S. Y. ^{[1
]}

Biradar, J. S. ^{[3
]}

Basawaraj, Raga ^{[2
]}

机构：

[1] Srikrupa Inst Pharmaceut Sci, Velkatta RD Siddipet, Medak 502277, Andhra Pradesh, India

[2] Karnataka Engn Pharm, Bidar 585403, Karnataka, India

[3] Gulbarga Univ, Dept Chem, Gulbarga 585106, Karnataka, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 18卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl 5-substituted-3-phenylindol-2-carboxylates (1a-d) were converted to 5-substituted-3-phenylindol-2-carbohydrazides (2a-d), by treating with hydrazine hydrate. Carbohydrazides 2 on reaction with carbon disulphide and potassium hydroxide yielded 5-substituted-3-phenyl-2-(5'-mercapto-1',3',4'-oxadiazol-2'-yl) indoles (3a-d), which on reaction with chloroacetic acid gave 2-(5'-substituted-3'-phenylindol-2'-yl)-1,3,4-oxadiazol-5-thioacetic acids (4a-d). These thioacetic acid derivatives 4 on reaction with orthophenylenediamine dihydrochloride furnished the title compounds 5. Newly synthesized compounds were screened for their anthelmintic activity.

引用

页码：321 / 324

页数：4

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