Functionalised allylsilanes from silylcopper reagents and allene.: A useful strategy for cyclopentane annulations

被引：44

作者：

Barbero, A ^{[1
]}

García, C ^{[1
]}

Pulido, FJ ^{[1
]}

机构：

[1] Univ Valladolid, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

TETRAHEDRON | 2000年 / 56卷 / 18期

关键词：

silylcupration; allene; allylsilane; cyclization;

D O I：

10.1016/S0040-4020(00)00129-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Silylcupration of allene using phenyldimethylsilylcopper or t-butyldiphenylsilylcopper followed by reaction with alpha,beta-unsaturated acyl chlorides, aldehydes or ketones affords allylsilane-containing divinyl ketones and oxoallylsilanes, respectively. They undergo highly stereocontrolled silicon-assisted intramolecular cyclizations when treated with protic or Lewis acid leading to cyclopentane ring-formation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2739 / 2751

页数：13

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