Predictors for the detection of prostate cancer and clinically significant prostate cancer using TRUS-guided biopsy in patients with negative initial biopsy results

被引:1
作者
Yoo, Sangjun [1 ]
Park, Juhyun [1 ]
Cho, Sung Yong [1 ]
Cho, Min Chul [1 ]
Ku, Ja Hyeon [2 ]
Son, Hwancheol [1 ]
Kwak, Cheol [2 ]
Kim, Hyeon Hoe [2 ]
Jeong, Hyeon [1 ]
机构
[1] Seoul Natl Univ, Dept Urol, Boramae Med Ctr, Sindaebang 2i Dong, Seoul 07061, South Korea
[2] Seoul Natl Univ Hosp, Dept Urol, Seoul, South Korea
关键词
Biopsy; Prostatectomy; Prostatic neoplasms; MRI-TARGETED BIOPSY; ACTIVE SURVEILLANCE; REPEAT BIOPSY; ULTRASOUND FUSION; EXPERIENCE; MANAGEMENT; ANTIGEN; LESION; RISK; MEN;
D O I
10.1007/s00345-018-2239-1
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We aimed to determine the predictors for the detection of prostate cancer and clinically significant prostate cancer in the setting of repeat prostate biopsy using trans-rectal ultrasonography-guided biopsy. A total of 636 patients who underwent repeat prostate biopsy were included. The patients were divided into two groups according to the repeat biopsy results (with vs. without prostate cancer). A multivariable analysis was performed to assess the predictors for the detection of prostate cancer and clinically significant prostate cancer. Prostate cancer was detected in 98 patients (15.4%). Although there was no difference in the prostate-specific antigen velocity, the prostate-specific antigen density was higher in the patients with prostate cancer at the initial (0.14 vs. 0.17 ng/mL/cc, p = 0.049) and repeat biopsies (0.17 vs. 0.26 ng/mL/cc, p < 0.001). The proportions of the patients who met the active surveillance criteria were as follows: 22.4% (Johns Hopkins), 30.6% (University of Toronto), 32.7% (University of California at San Francisco), 30.6% (Prostate Cancer Research International Active Surveillance), 27.6% (Memorial Sloan Kettering Cancer Center), and 13.3% (University of Miami). In the multivariable analysis, age, hypoechoic lesion on trans-rectal ultrasonography, and prostate-specific antigen density at the repeat biopsy were the significant predictors for prostate cancer and clinically significant prostate cancer. Trans-rectal ultrasonography before repeat prostate biopsy and the prostate-specific antigen density are useful for selecting patients with a high probability for prostate cancer if repeat trans-rectal ultrasonography-guided biopsy is considered. In addition, these are also helpful for detecting clinically significant prostate cancer.
引用
收藏
页码:1047 / 1053
页数:7
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