A case of sulphasalazine-induced DRESS syndrome with delayed acute interstitial nephritis

被引：32

作者：

Augusto, Jean-Francois ^{[1
,2
,3
]}

Sayegh, Johnny ^{[1
]}

Simon, Amelie ^{[1
]}

Croue, Anne ^{[4
]}

Chennebault, Jean-Marie ^{[5
]}

Cousin, Maud ^{[1
,3
]}

Subra, Jean-Francois ^{[1
,3
]}

机构：

[1] CHU Angers, Serv Nephrol Dialyse Transplantat, F-49933 Angers, France

[2] CHU Angers, Serv Reanimat Med & Med Hyperbare, F-49933 Angers, France

[3] Univ Angers, UPRES EA 3863, F-49035 Angers, France

[4] CHU Angers, Dept Pathol Cellulaire & Tissulaire, F-49933 Angers, France

[5] CHU Angers, Dept Malad Infect & Trop, F-49933 Angers, France

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2009年 / 24卷 / 09期

关键词：

acute tubulointerstitial nephritis; DRESS syndrome; HHV-6; sulphasalazine; HYPERSENSITIVITY-SYNDROME; INFECTION; RISK;

D O I：

10.1093/ndt/gfp277

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a rare and severe drug-induced hypersensitivity syndrome characterized by haematological abnormalities (hypereosinophilia and/or mononucleosis) and multiorgan involvement. Renal failure has been rarely described. We report the case of a 77-year-old female with sulphasalazine-induced DRESS syndrome who improved rapidly on corticosteroid treatment. After prednisone withdrawal, the patient developed renal failure that necessitated a session of haemodialysis. A kidney biopsy showed acute tubulointerstitial nephritis with an intense lymphocytic infiltrate and tubular necrosis. Kidney function normalized after a further 2 weeks of corticosteroid treatment. This is the first histologically proven case of acute tubulointerstitial nephritis in the setting of sulphasalazine-induced DRESS syndrome.

引用

页码：2940 / 2942

页数：3

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