Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa

被引：40
|
作者：
Sobocka, MB
Sobocki, T
Babinska, A
Hartwig, JH
Li, MG
Ehrlich, YH
Kornecki, E
机构：
[1] Suny Downstate Med Ctr, Dept Anat & Cell Biol, Brooklyn, NY 11203 USA
[2] CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY USA
[3] CUNY Coll Staten Isl, Neurosci Program, Staten Isl, NY USA
[4] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY USA
[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Div Expt Med & Hematol Oncol, Boston, MA USA
来源：
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2004年 / 24卷 / 1-2期
关键词：
F11; receptor; F11R; junctional adhesion molecule; JAM; JAM-1; JAM-A; PI-3; kinase; calcium ions; platelet aggregation; cell adhesion molecule (CAM); F11 receptor dimerization; integrin GPIIIa;
D O I：
10.1081/RRS-120034252
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The F11 receptor (F11R) (a.k.a. Junctional Adhesion Molecule, JAM) was first identified in human platelets as a 32/35 kDa protein duplex that serves as receptor for a functional monoclonal antibody that activates platelets. We have sequenced and cloned the F11R and determined that it is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. The signaling pathways involved in F11R-induced platelet activation were examined in this investigation. The binding of M.Ab.F11 to the platelet F11R resulted in granule secretion and aggregation.
引用
收藏
页码：85 / 105
页数：21
相关论文
共 43 条
  • [1] The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression
    Kamila Czubak-Prowizor
    Anna Babinska
    Maria Swiatkowska
    Molecular and Cellular Biochemistry, 2022, 477 : 79 - 98
  • [2] The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression
    Czubak-Prowizor, Kamila
    Babinska, Anna
    Swiatkowska, Maria
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2022, 477 (01) : 79 - 98
  • [3] Enhanced levels of F11R receptor (F11R/JAM-1/JAM-A) in PCOS patients.
    Muneyyirci-Delale, O.
    Babinska, A.
    Nacharaju, V. L.
    Dalloul, M.
    Kornecki, E.
    FERTILITY AND STERILITY, 2007, 88 : S186 - S186
  • [4] Expression of a recombinant protein of the platelet F11 receptor (F11R) (JAM-1/JAM-A) in insect cells: F11R is naturally phosphorylated in the extracellular domain
    Kedees, MH
    Babinska, A
    Hussain, MM
    Kornecki, E
    Deitch, J
    Ehrlich, YH
    Swiatkowska, M
    PLATELETS, 2005, 16 (02) : 99 - 109
  • [5] Expression of a recombinant protein of the platelet F11 receptor (F11R) (JAM-1/JAM-A) in insect cells: F11R is naturally phosphorylated in the extracellular domain (March, pg 99, 2005)
    Kedees, MH
    Babinska, A
    Swiatkowska, M
    Deitch, J
    Hussain, MM
    Ehrlich, YH
    Kornecki, E
    PLATELETS, 2005, 16 (3-4) : 249 - 249
  • [6] Silencing the F11R gene confirms the critical role of the F11 receptor (F11R/JAM-A) in platelet adhesion to inflamed endothelium and in atherosclerosis
    Azari, B. M.
    Marmur, J. D.
    Salifu, M. O.
    Ehrlich, Y. H.
    Kornecki, E.
    Babinska, A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 233 - 233
  • [7] Development of new antiatherosclerotic and antithrombotic drugs utilizing F11 receptor (F11r/JAM-A) peptides
    Babinska, Anna
    Clement, C.C.
    Swiatkowska, M.
    Szymanski, J.
    Shon, A.
    Ehrlich, Y.H.
    Kornecki, E.
    Salifu, M.O.
    Biopolymers - Peptide Science Section, 2014, 102 (04): : 322 - 334
  • [8] Development of New Antiatherosclerotic and Antithrombotic Drugs Utilizing F11 Receptor (F11R/JAM-A) Peptides
    Babinska, A.
    Clement, C. C.
    Swiatkowska, M.
    Szymanski, J.
    Shon, A.
    Ehrlich, Y. H.
    Kornecki, E.
    Salifu, M. O.
    BIOPOLYMERS, 2014, 102 (04) : 322 - 334
  • [9] Association of plasma levels of F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) with human atherosclerosis
    Cavusoglu, Erdal
    Kornecki, Elizabeth
    Sobocka, Malgorzata B.
    Babinska, Anna
    Ehrlich, Yigal H.
    Chopra, Vineet
    Yanamadala, Sunitha
    Ruwende, Cyril
    Salifu, Moro O.
    Clark, Luther T.
    Eng, Calvin
    Pinsky, David J.
    Marmur, Jonathan D.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (18) : 1768 - 1776
  • [10] Peptides Inhibitors of F11R/JAM-A Adhesion Molecules
    Clement, Cristina Corina
    Babinska, Anna
    Kornecki, Elizabeth
    Ehrlich, Yigal H.
    Philipp, Manfred
    FASEB JOURNAL, 2008, 22
12345