The relative length of dual-target conjugated on iron oxide nanoparticles plays a role in brain glioma targeting

被引：14

作者：

Ai, Penghui ^{[1
]}

Wang, Hao ^{[3
]}

Liu, Kang ^{[2
]}

Wang, Tingjian ^{[1
]}

Gu, Wei ^{[2
]}

Ye, Ling ^{[2
]}

Yan, Changxiang ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China

[2] Capital Med Univ, Sch Pharmaceut Sci, Beijing 100069, Peoples R China

[3] Capital Med Univ, Sch Basic Med Sci, Dept Anat, Beijing 100069, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 32期

基金：

北京市自然科学基金;

关键词：

RESONANCE-IMAGING CONTRAST; DRUG-DELIVERY; AGENTS; NANOCARRIERS; CANCER; PROBES; SPIONS;

D O I：

10.1039/c7ra02102j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of superparamagnetic iron oxide nanoparticles as a magnetic resonance (MR) nanoprobe for brain glioma is limited by the insufficient specificity and accumulation at the tumor site. To increase brain glioma-targeting specificity and improve MR contrast effect, dual-target has been employed. However, up to now, little work has been done to ascertain if the relative length of the dual-target plays a role in targeting. Herein, we prepared Cy5.5-labeled Fe3O4 NPs with chlorotoxin (CTX)/PEGylated folic acid (PEG-FA) dual-target of different relative lengths. The effect of dual-target relative length on targeting specificity was investigated by in vitro cellular uptake and in vivo MR/NIR imaging in brain glioma-bearing mice. It was demonstrated that the targeting ability of the dual-targeting Fe3O4 NPs could be modulated by adjusting the relative length of dual-target, suggesting that the relative length of dual-target plays a role in brain glioma targeting.

引用

页码：19954 / 19959

页数：6

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