Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity

被引：29

作者：

Ozkur, E. ^{[1
]}

Karadag, A. S. ^{[2
]}

Ustuner, P. ^{[3
]}

Aksoy, B. ^{[4
,5
]}

Esme, P. ^{[6
]}

Caliskan, E. ^{[6
]}

Akoglu, G. ^{[6
]}

Kalkan, G. ^{[7
]}

Demirseren, D. D. ^{[8
]}

Polat, M. ^{[9
]}

Ozden, M. G. ^{[10
]}

Kilinc, F. ^{[9
]}

Yalcinkaya Iyidal, A. ^{[11
]}

Kivanc Altunay, I. ^{[1
]}

Turkmen, M. ^{[12
]}

Ugurer, E. ^{[1
]}

Baysak, S. ^{[13
]}

Fettahlioglu Karaman, B. ^{[14
]}

Mammadli, K. ^{[15
]}

Baykal Selcuk, L. ^{[16
]}

Turkoglu, Z. ^{[17
]}

Atci, T. ^{[17
]}

Didar Balci, D. ^{[18
]}

Adisen, E. ^{[19
]}

Temel, B. ^{[19
]}

Aktan, S. ^{[20
]}

Kacar, N. ^{[21
]}

Gunduz, K. ^{[22
]}

Turel Ertmertcan, A. ^{[22
]}

Ozdemir, M. ^{[23
]}

Cakiter, A. Unal ^{[23
]}

Colgecen, E. ^{[24
]}

Ucmak, D. ^{[25
]}

Kelekci, H. ^{[26
]}

Ataseven, A. ^{[27
]}

Durmaz, K. ^{[27
]}

Kaya Ozden, H. ^{[28
]}

Engin, B. ^{[29
]}

Yazici, S. ^{[30
]}

Alpsoy, E. ^{[15
]}

机构：

[1] Sisli Hamidiye Etfal Training & Res Hosp, Univ Hlth Sci, Dept Dermatol, TR-34100 Istanbul, Turkey

[2] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Dermatol, Istanbul, Turkey

[3] Demiroglu Bilim Univ, Fac Med, Dept Dermatol, Istanbul, Turkey

[4] Bahcesehir Univ, Fac Med, Dept Dermatol, Istanbul, Turkey

[5] VM Med Pk Kocaeli Hosp, Kocaeli, Kocaeli, Turkey

[6] Gulhane Training & Res Hosp, Dept Dermatol, Ankara, Turkey

[7] Ankara Yildirim Beyazit Univ, Fac Med, Dept Dermatol, Ankara, Turkey

[8] Ankara Bilkent City Hosp, Dept Dermatol, Ankara, Turkey

[9] Abant Izzet Baysal Univ, Fac Med, Dept Dermatol, Bolu, Turkey

[10] Ondokuz Mayis Univ, Fac Med, Dept Dermatol, Samsun, Turkey

[11] Kecioren Training & Res Hosp, Dept Dermatol, Ankara, Turkey

[12] Izmir Bozyaka Training & Res Hosp, Dept Dermatol, Izmir, Turkey

[13] Sultan Abdulhamit Han Training & Res Hosp, Dept Dermatol, Istanbul, Turkey

[14] Cukurova Univ, Fac Med, Dept Dermatol, Adana, Turkey

[15] Akdeniz Univ, Dept Dermatol, Fac Med, Antalya, Turkey

[16] Karadeniz Tech Univ, Fac Med, Dept Dermatol, Trabzon, Turkey

[17] Haseki Training & Res Hosp, Dept Dermatol, Istanbul, Turkey

[18] Tepecik Training & Res Hosp, Dept Dermatol, Izmir, Turkey

[19] Gazi Univ, Fac Med, Dept Dermatol, Ankara, Turkey

[20] Dokuz Eylul Univ, Fac Med, Dept Dermatol, Izmir, Turkey

[21] Pamukkale Univ, Fac Med, Dept Dermatol, Denizli, Turkey

[22] Celal Bayar Univ, Fac Med, Dept Dermatol, Manisa, Turkey

[23] Medipol Univ, Fac Med, Dept Dermatol, Istanbul, Turkey

[24] Yozgat Bozok Univ, Fac Med, Dept Dermatol, Yozgat, Turkey

[25] Dicle Univ, Fac Med, Dept Dermatol, Diyarbakir, Turkey

[26] Izmir Katip Celebi Univ, Fac Med, Dept Dermatol, Izmir, Turkey

[27] Necmettin Erbakan Univ, Meram Fac Med, Dept Dermatol, Konya, Turkey

[28] Derince Training & Res Hosp, Dept Dermatol, Kocaeli, Turkey

[29] Istanbul Univ, CerrahpaSa Med Fac, Dept Dermatol, Istanbul, Turkey

[30] Uludag Univ, Fac Med, Dept Dermatol, Bursa, Turkey

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2021年 / 46卷 / 03期

关键词：

D O I：

10.1111/ced.14478

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.

引用

页码：532 / 540

页数：9

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