Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity

被引：12

作者：

Emery, Sophie ^{[1
]}

Haeberling, Isabelle ^{[1
]}

Berger, Gregor ^{[1
]}

Baumgartner, Noemi ^{[1
]}

Strumberger, Michael ^{[2
]}

Albermann, Mona ^{[1
]}

Nalani, Kristin ^{[3
]}

Schmeck, Klaus ^{[2
]}

Erb, Suzanne ^{[4
]}

Bachmann, Silke ^{[5
,6
]}

Woeckel, Lars ^{[2
,7
]}

Mueller-Knapp, Ulrich ^{[8
]}

Contin-Waldvogel, Brigitte ^{[9
]}

Rhiner, Bruno ^{[10
]}

Walitza, Susanne ^{[1
,11
,12
,13
]}

Hersberger, Martin ^{[13
,14
]}

Drechsler, Renate ^{[1
]}

机构：

[1] Univ Zurich, Psychiat Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, CH-8032 Zurich, Switzerland

[2] Univ Basel, Psychiat Univ Hosp Basel, Res Dept Child & Adolescent Psychiat, CH-4002 Basel, Switzerland

[3] Univ Hosp Zurich, Clin Psychosomat Med & Psychiat, CH-8091 Zurich, Switzerland

[4] Child & Adolescent Psychiat Serv St Gallen, CH-9004 St Gallen, Switzerland

[5] Univ Hosp Geneva, Dept Psychiat, CH-1226 Thonex, Switzerland

[6] Martin Luther Univ Halle Wittenberg, Dept Psychiat Psychotherapy, Psychosomat Med, Med Fac, D-06112 Halle, Germany

[7] Clienia Littenheid AG, CH-9573 Littenheid, Switzerland

[8] Child & Adolescent Psychiat Klin Sonnenhof, CH-9608 Ganterschwil, Switzerland

[9] Child & Adolescent Psychiat Serv Baselland, CH-4410 Liestal, Switzerland

[10] Child & Adolescent Psychiat Serv Thurgau, CH-8570 Weinfelden, Switzerland

[11] Univ Zurich, Neurosci Ctr Zurich, CH-8057 Zurich, Switzerland

[12] Swiss Fed Inst Technol, CH-8057 Zurich, Switzerland

[13] Univ Zurich, Ctr Integrat Human Physiol Zurich, CH-8057 Zurich, Switzerland

[14] Univ Childrens Hosp Zurich, Div Clin Chem & Biochem, CH-8032 Zurich, Switzerland

来源：

NUTRIENTS | 2020年 / 12卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

omega-3 polyunsaturated fatty acid; EPA; DHA; depression; depression severity; verbal memory; children; adolescents; cognition; POLYUNSATURATED FATTY-ACIDS; COGNITIVE FUNCTION; OMEGA-3-FATTY-ACID SUPPLEMENTATION; NEUROCOGNITIVE FUNCTION; EXECUTIVE FUNCTION; CLINICAL-TRIALS; MOOD DISORDERS; LIFE-SPAN; METAANALYSIS; OMEGA-3;

D O I：

10.3390/nu12123630

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been described as positively associated with cognitive functioning. Current meta-analyses have identified eicosapentaenoic acid (EPA) as potentially more effective than docosahexaenoic acid (DHA). An especially vulnerable subgroup that might benefit from these beneficial effects are depressed youths. In this study, we examined associations between red blood cell (RBC) DHA and EPA levels and depression severity and verbal memory performance in a sample of 107 moderately (n = 63) and severely (n = 44) depressed youths. The findings showed that youths with high RBC EPA levels had steeper learning curves compared to those with moderate or low RBC EPA levels (Pillai's Trace = 0.195, p = 0.027, eta(2)(p) = 0.097). No associations between RBC DHA levels or depression severity and verbal memory performance were observed. Our results further confirm previous findings indicating a more important role of EPA compared to DHA in relation to cognitive functioning. Future research should further investigate the differential role of EPA and DHA concerning cognitive functioning in depressed youths. Evidence supporting beneficial supplementation effects could potentially establish a recommendation for a natural and easily accessible intervention for cognitive improvement or remission.

引用

页码：1 / 25

页数：25

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[31] A Cognitive-Emotional Biomarker for Predicting Remission with Antidepressant Medications: A Report from the iSPOT-D Trial [J].