Synthesis of 4-functionalized aryl-3,5-diacyl-1,4-dihydropyridines

被引：26

作者：

Bennasar, ML ^{[1
]}

Roca, T ^{[1
]}

Monerris, M ^{[1
]}

Juan, C ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

TETRAHEDRON | 2002年 / 58卷 / 40期

关键词：

dihydropyridines; pyridinium salts; magnesium and compounds; copper and compounds;

D O I：

10.1016/S0040-4020(02)00941-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The valuable N-unsubstituted 4-aryl-3,5-diacyl-1,4-dihydropyridines 12b-f, bearing an electron-withdrawing substituent at the benzene ring, have been synthesized by the copper-mediated addition of functionalized arylmagnesium reagents 2b-f to N-benzhydrylpyridinium salt 9, followed by acylation with trichloroacetic anhydride and the subsequent haloform reaction and N-deprotection. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8099 / 8106

页数：8

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