Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection

被引：8
|
作者：
Nirei, Kazushige [1 ]
Nakamura, Hitomi [1 ]
Matsuoka, Shunichi [1 ]
Yamana, Yoichiro [1 ]
Yoda, Shunichi [2 ]
Hirayama, Atsushi [2 ]
Moriyama, Mitsuhiko [1 ]
机构：
[1] Nihon Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan
[2] Nihon Univ, Sch Med, Dept Med, Div Cardiol, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2017年 / 56卷 / 07期
关键词：
chronic hepatitis C; ledipasvir and sofosbuvir; ventricular tachycardia; C VIRUS-INFECTION; AMIODARONE; MECHANISMS;
D O I：
10.2169/internalmedicine.56.7948
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both serious ventricular tachycardia (VT) that converted spontaneously to sinus rhythm, without treatment, and both patients had good outcomes. These cases suggest that LDV/SOF may be associated with an increased risk of heart-related events.
引用
收藏
页码：787 / 790
页数：4
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