Global trends in the burden of liver cancer

被引:48
作者
Are, Chandrakanth [1 ]
Meyer, Bria [1 ]
Stack, Apollo [2 ]
Ahmad, Humera [3 ]
Smith, Lynette [4 ]
Qian, Biyun [5 ]
Song, Tianqiang [6 ]
Chowdhury, Sanjib [7 ]
机构
[1] Univ Nebraska Med Ctr, Div Surg Oncol, Dept Surg, Omaha, NE USA
[2] Univ Nebraska Med Ctr, Coll Med, Omaha, NE USA
[3] Gunderson Med Fdn, Dept Surg, La Crosse, WI USA
[4] Univ Nebraska Med Ctr, Coll Publ Hlth, Omaha, NE USA
[5] Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai, Peoples R China
[6] Tianjin Med Univ Canc Inst & Hosp, Dept Hepatobiliary Tumor, Tianjin, Peoples R China
[7] Boston Univ, Med Ctr, Dept Med, Gastroenterol Sect, Boston, MA USA
关键词
burden; demographic shift; Human Development Index; liver cancer; WHO regions; HEPATOCELLULAR-CARCINOMA; MORTALITY; CHALLENGES; DIAGNOSIS; AUSTRALIA;
D O I
10.1002/jso.24518
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: The aim of this study is to describe the influence of geography, socio-economic development, and demographic shift on the trends in global incidence, mortality, and prevalence of liver cancer (LC). METHODS: Data (2012-2030) relating to LC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012 and analyzed to evaluate trends in incidence, mortality, and prevalence. RESULTS: The results of our study document a rising global burden of LC with the maximum impact in the WPRO region. We did not observe a definite association between LC and higher socio-economic status with the highest burden in the MHD region. For the MHD region, we noticed age reversal in burden from the younger age group currently to the older age group in the future (2030). Another finding is the high burden and early onset of disease in some low-income countries such as Mongolia, Lao PDR, and Vietnam. CONCLUSION: The results of our study demonstrate a rising global burden of LC with some significant but uneven trends based on geography, age, and socio-economic status. This information can be used to shape policy and aid strategic targeting of resources to areas with the highest burden.
引用
收藏
页码:591 / 602
页数:12
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