Synthesis of novel ellipticine analogues and their inhibition of moloney leukaemia reverse transcriptase

被引：41

作者：

Timari, G

Soos, T

Hajos, G

Messmer, A

Nacsa, J

Molnar, J

机构：

[1] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1525 BUDAPEST,HUNGARY

[2] ALBERT SZENT GYORGYI MED UNIV,INST MICROBIOL,H-6701 SZEGED,HUNGARY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(96)00521-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested on Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID50 was found to be in the range of 2.8 to 4.5 x 10(-5) M. \ Copyright (C) 1996 Elsevier Science Ltd

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页码：2831 / 2836

页数：6

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