HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture

被引：2

作者：

Barr, David A. ^{[1
,2
]}

Kerkhoff, Andrew D. ^{[3
]}

Schutz, Charlotte ^{[2
]}

Ward, Amy M. ^{[2
]}

Davies, Gerry R. ^{[4
]}

Wilkinson, Robert J. ^{[2
,5
,6
]}

Meintjes, Graeme ^{[2
]}

机构：

[1] Univ Liverpool, Inst Infect & Global Hlth, Wellcome Liverpool Glasgow Ctr Global Hlth Res, Liverpool, Merseyside, England

[2] Univ Cape Town, Dept Med, Inst Infect Dis & Mol Med, Wellcome Ctr Infect Dis Res Africa, Cape Town, South Africa

[3] Univ Calif San Francisco, Sch Med, Dept Med, Div Infect Dis, San Francisco, CA USA

[4] Univ Liverpool, Inst Global Hlth, Dept Clin Infect Microbiol & Immunol, Liverpool, Merseyside, England

[5] Imperial Coll London, Dept Med, London, England

[6] Francis Crick Inst, London, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2018年 / 56卷 / 05期

基金：

英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金;

关键词：

Mycobacterium tuberculosis; blood culture; human immunodeficiency virus; ADULTS; PREVALENCE; BACTEREMIA; PROTOCOL; SEPSIS;

D O I：

10.1128/JCM.01914-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed the additional diagnostic yield for Mycobacterium tuberculosis bloodstream infection (BSI) by doing more than one tuberculosis (TB) blood culture from HIV-infected inpatients. In a retrospective analysis of two cohorts based in Cape Town, South Africa, 72/99 (73%) patients with M. tuberculosis BSI were identified by the first of two blood cultures during the same admission, with 27/99 (27%; 95% confidence interval [CI], 18 to 36%) testing negative on the first culture but positive on the second. In a prospective evaluation of up to 6 blood cultures over 24 h, 9 of 14 (65%) patients with M. tuberculosis BSI had M. tuberculosis grow on their first blood culture; 3 more patients (21%) were identified by a second independent blood culture at the same time point, and the remaining 2 were diagnosed only on the 4th and 6th blood cultures. Additional blood cultures increase the yield for M. tuberculosis BSI, similar to what is reported for nonmycobacterial BSI.

引用

页数：5

共 18 条

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