Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer

被引:141
作者
Donnem, T. [1 ,2 ]
Kilvaer, T. K. [1 ]
Andersen, S. [1 ]
Richardsen, E. [3 ,4 ]
Paulsen, E. E. [1 ,2 ]
Hald, S. M. [2 ]
Al-Saad, S. [3 ,4 ]
Brustugun, O. T. [5 ]
Helland, A. [5 ,6 ]
Lund-Iversen, M. [7 ]
Solberg, S. [8 ]
Gronberg, B. H. [9 ,10 ]
Wahl, S. G. F. [11 ]
Helgeland, L. [12 ]
Flotten, O. [13 ]
Pohl, M. [14 ]
Al-Shibli, K. [15 ]
Sandanger, T. M. [16 ]
Pezzella, F. [17 ]
Busund, L. T. [3 ,4 ]
Bremnes, R. M. [1 ,2 ]
机构
[1] Univ Hosp North Norway, Dept Oncol, Tromso, Norway
[2] Arctic Univ Norway, Inst Clin Med, Tromso, Norway
[3] Univ Hosp North Norway, Dept Clin Pathol, Tromso, Norway
[4] Arctic Univ Norway, Inst Med Biol, Tromso, Norway
[5] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Oncol, Oslo, Norway
[6] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, Oslo, Norway
[7] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Pathol, Oslo, Norway
[8] Oslo Univ Hosp, Rikshosp, Dept Cardiothorac Surg, Oslo, Norway
[9] Univ Trondheim Hosp, St Olavs Hosp, Canc Clin, Trondheim, Norway
[10] Norwegian Univ Sci & Technol, European Palliat Care Res Ctr, Dept Canc Res & Mol Med, N-7034 Trondheim, Norway
[11] Univ Trondheim Hosp, St Olavs Hosp, Dept Pathol & Med Genet, Trondheim, Norway
[12] Haukeland Hosp, Dept Pathol, N-5021 Bergen, Norway
[13] Haukeland Hosp, Dept Thorac Med, N-5021 Bergen, Norway
[14] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark
[15] Nordland Hosp, Dept Pathol, Bodo, England
[16] Artic Univ Tromso, Dept Community Med, Tromso, Norway
[17] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England
关键词
immunoscore; T cells; TNM-I; NSCLC; lung cancer; TUMOR-INFILTRATING LYMPHOCYTES; T-CELLS; IMMUNE CONTEXTURE; PROGNOSTIC VALUE; CLASSIFICATION; SURVIVAL; RECURRENCE; EXPRESSION; CARCINOMA; DENSITY;
D O I
10.1093/annonc/mdv560
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates and appears highly promising as a supplement to the tumor-node-metastasis (TNM) classification of various tumors. In colorectal cancer, an international task force has initiated prospective multicenter studies aiming to implement TNM-Immunoscore (TNM-I) in a routine clinical setting. In breast cancer, recommendations for the evaluation of tumor-infiltrating lymphocytes (TILs) have been proposed by an international working group. Regardless of promising results, there are potential obstacles related to implementing TNM-I into the clinic. Diverse methods may be needed for different malignancies and even within each cancer entity. Nevertheless, a uniform approach across malignancies would be advantageous. In nonsmall-cell lung cancer (NSCLC), there are several previous reports indicating an apparent prognostic importance of TILs, but studies on TILs in a TNM-I setting are sparse and no general recommendations are made. However, recently published data is promising, evoking a realistic hope of a clinical useful NSCLC TNM-I. This review will focus on the TNM-I potential in NSCLC and propose strategies for clinical implementation of a TNM-I in resected NSCLC.
引用
收藏
页码:226 / 232
页数:8
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