Angiotensin-converting enzyme gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients

被引：7

作者：

Araz, M ^{[1
]}

Aynacioglu, S

Okan, V

Akdemir, Y

Aktaran, S

机构：

[1] Gaziantep Univ, Fac Med, Dept Internal Med, TR-27070 Gaziantep, Turkey

[2] Gaziantep Univ, Fac Med, Dept Pharmacol, TR-27070 Gaziantep, Turkey

[3] Gaziantep Univ, Fac Med, Dept Cardiol, TR-27070 Gaziantep, Turkey

来源：

ACTA CARDIOLOGICA | 2002年 / 57卷 / 04期

关键词：

angiotensin-converting enzyme; polymorphism; type 2 diabetes mellitus; coronary heart disease;

D O I：

10.2143/AC.57.4.2005424

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective - It has been suggested that the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) may be associated with atherosclerosis. The aim of the study was to examine the association between ACE gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients. Methods and results - A total of 152 (97 female, 55 male) type 2 diabetic patients were included into the study. All patients underwent myocardial perfusion scintigraphic examination and forty-five of them with a perfusion defect underwent coronary angiography. Thirty-eight patients with a coronary stenosis of more than 50% on coronary angiography were considered as having coronary heart disease. The I/D polymorphism was determined by polymerase chain reaction. There was no statistically significant difference in genotypic and allelic frequencies of the ACE I/D polymorphism among patients with and without coronary heart disease (DD:ID:II (%), 32:58:11 and 39:44:17, respectively). Conclusions - ACE gene polymorphism is not a significant parameter to determine coronary heart disease in Turkish type 2 diabetic patients.

引用

页码：265 / 269

页数：5

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