Correlation and thermodynamic analysis of solubility of diphenhydramine hydrochloride in pure and binary solvents

被引：59
作者：
Du, Shichao [1 ,2 ]
Wang, Yan [1 ,2 ]
Li, Jianyu [1 ]
Wu, Songgu [1 ,2 ]
Dun, Weiqiang [1 ,2 ]
Song, Xiaopeng [1 ,2 ]
Wang, Jingkang [1 ,2 ]
Gong, Junbo [1 ,2 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL THERMODYNAMICS | 2016年 / 93卷
基金：
中国国家自然科学基金;
关键词：
Diphenhydramine hydrochloride; Solubility; Maximum; Activity coefficient; Thermodynamic properties; ORGANIC-SOLVENTS; MIXTURES; WATER; TEMPERATURES; SYSTEMS;
D O I：
10.1016/j.jct.2015.09.032
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The solubility of diphenhydramine hydrochloride (DH) in four pure solvents (methanol, ethanol, acetone and ethyl acetate) and two binary solvents (ethanol + ethyl acetate) and (ethanol + acetone) was determined at temperatures from (278.15 to 323.15) K. The experimental solubility of DH is well correlated by the modified Apelblat equation, the CNIBS/R-K equation and the hybrid model, respectively. All the measured solubility of DH shows temperature dependence, In binary mixtures, the solubility curve displays a maximum with the solvent composition changing, particularly, the maximum point increases with temperature. Moreover, the activity coefficients as well as thermodynamic properties of mixing were obtained and discussed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：132 / 142
页数：11
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