Targeting adeno-associated virus and adenoviral gene therapy for hepatocellular carcinoma

被引：36

作者：

Wang, Yi-Gang ^{[1
]}

Huang, Pan-Pan ^{[1
]}

Zhang, Rong ^{[1
]}

Ma, Bu-Yun ^{[1
]}

Zhou, Xiu-Mei ^{[1
]}

Sun, Yan-Fang ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Sch Life Sci, Xinyuan Inst Med & Biotechnol, Hangzhou 310018, Zhejiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hepatocellular carcinoma; Adeno-associated virus; Adenovirus; Virus vectors; MANGANESE SUPEROXIDE-DISMUTASE; GOLGI PROTEIN 73; ONCOLYTIC ADENOVIRUS; ANTITUMOR-ACTIVITY; TELOMERASE ACTIVITY; LIVER-CANCER; IN-VITRO; TUMOR-GROWTH; REPLICATING ADENOVIRUS; MICRORNA DELIVERY;

D O I：

10.3748/wjg.v22.i1.326

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Human hepatocellular carcinoma (HCC) heavily endangers human heath worldwide. HCC is one of most frequent cancers in China because patients with liver disease, such as chronic hepatitis, have the highest cancer susceptibility. Traditional therapeutic approaches have limited efficacy in advanced liver cancer, and novel strategies are urgently needed to improve the limited treatment options for HCC. This review summarizes the basic knowledge, current advances, and future challenges and prospects of adeno-associated virus (AAV) and adenoviruses as vectors for gene therapy of HCC. This paper also reviews the clinical trials of gene therapy using adenovirus vectors, immunotherapy, toxicity and immunological barriers for AAV and adenoviruses, and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.

引用

页码：326 / 337

页数：12

共 117 条

[1] Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I [J].

Berraondo, Pedro ;

Di Scala, Marianna ;

Korolowicz, Kyle ;

Thampi, Linta M. ;

Otano, Itziar ;

Suarez, Lester ;

Fioravanti, Jessica ;

Aranda, Fernando ;

Ardaiz, Nuria ;

Yang, Junming ;

Kallakury, Bhaskar V. ;

Tucker, Robin D. ;

Vasquez, Marcos ;

Menne, Stephan ;

Prieto, Jesus ;

Gonzalez-Aseguinolaza, Gloria .

JOURNAL OF HEPATOLOGY, 2015, 63 (02) :329-336

[2] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[3] CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia [J].

Brentjens, Renier J. ;

Davila, Marco L. ;

Riviere, Isabelle ;

Park, Jae ;

Wang, Xiuyan ;

Cowell, Lindsay G. ;

Bartido, Shirley ;

Stefanski, Jolanta ;

Taylor, Clare ;

Olszewska, Malgorzata ;

Borquez-Ojeda, Oriana ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Bernal, Yvette ;

Rijo, Ivelise V. ;

Hedvat, Cyrus ;

Kobos, Rachel ;

Curran, Kevin ;

Steinherz, Peter ;

Jurcic, Joseph ;

Rosenblat, Todd ;

Maslak, Peter ;

Frattini, Mark ;

Sadelain, Michel .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (177)

[4] Potentiating Cancer Immunotherapy Using an Oncolytic Virus [J].

Bridle, Byram W. ;

Stephenson, Kyle B. ;

Boudreau, Jeanette E. ;

Koshy, Sandeep ;

Kazdhan, Natasha ;

Pullenayegum, Eleanor ;

Brunelliere, Jerome ;

Bramson, Jonathan L. ;

Lichty, Brian D. ;

Wan, Yonghong .

MOLECULAR THERAPY, 2010, 18 (08) :1430-1439

[5] Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene [J].

Cao, X. ;

Yang, M. ;

Wei, R-C ;

Zeng, Y. ;

Gu, J-F ;

Huang, W-D ;

Yang, D-Q ;

Li, H-L ;

Ding, M. ;

Wei, N. ;

Zhang, K-J ;

Xu, B. ;

Liu, X-R ;

Qian, Q-J ;

Liu, X-Y .

GENE THERAPY, 2011, 18 (08) :765-777

[6] Correction of Hunter syndrome in the MPSII mouse model by AAV2/8-mediated gene delivery [J].

Cardone, M ;

Polito, VA ;

Pepe, S ;

Mann, L ;

D'Azzo, A ;

Auricchio, A ;

Ballabio, A ;

Cosma, MP .

HUMAN MOLECULAR GENETICS, 2006, 15 (07) :1225-1236

[7] An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance [J].

Cerullo, Vincenzo ;

Diaconu, Iulia ;

Romano, Valentina ;

Hirvinen, Mari ;

Ugolini, Matteo ;

Escutenaire, Sophie ;

Holm, Sirkka-Liisa ;

Kipar, Anja ;

Kanerva, Anna ;

Hemminki, Akseli .

MOLECULAR THERAPY, 2012, 20 (11) :2076-2086

[8] Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients [J].

Cerullo, Vincenzo ;

Pesonen, Sari ;

Diaconu, Iulia ;

Escutenaire, Sophie ;

Arstila, Petteri T. ;

Ugolini, Matteo ;

Nokisalmi, Petri ;

Raki, Mari ;

Laasonen, Leena ;

Sarkioja, Merja ;

Rajecki, Maria ;

Kangasniemi, Lotta ;

Guse, Kilian ;

Helminen, Andreas ;

Ahtiainen, Laura ;

Ristimaki, Ari ;

Raisanen-Sokolowski, Anne ;

Haavisto, Elina ;

Oksanen, Minna ;

Karli, Eerika ;

Karioja-Kallio, Aila ;

Holm, Sirkka-Liisa ;

Kouri, Mauri ;

Joensuu, Timo ;

Kanerva, Anna ;

Hemminki, Akseli .

CANCER RESEARCH, 2010, 70 (11) :4297-4309

[9] Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy [J].

Chandler, Randy J. ;

LaFave, Matthew C. ;

Varshney, Gaurav K. ;

Trivedi, Niraj S. ;

Carrillo-Carrasco, Nuria ;

Senac, Julien S. ;

Wu, Weiwei ;

Hoffmann, Victoria ;

Elkahloun, Abdel G. ;

Burgess, Shawn M. ;

Venditti, Charles P. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (02) :870-880

[10] Oncolytic adenovirus-mediated shRNA against Apollon inhibits tumor cell growth and enhances antitumor effect of 5-fluorouracil [J].

Chu, L. ;

Gu, J. ;

Sun, L. ;

Qian, Q. ;

Qian, C. ;

Liu, X. .

GENE THERAPY, 2008, 15 (07) :484-494

← 1 2 3 4 5 6 7 8 9 10 →