The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol-acrylate Michael addition reactions

被引：18

作者：

Auty, Sam E. R. ^{[1
]}

Andren, Oliver ^{[2
]}

Malkoch, Michael ^{[2
]}

Rannard, Steven P. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] KTH Royal Inst Technol, Sch Chem Engn, Dept Fibre & Polymer Technol, SE-10044 Stockholm, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 50期

基金：

英国工程与自然科学研究理事会;

关键词：

CLICK-CHEMISTRY; DENDRITIC ARCHITECTURES; SCAFFOLDS; POLYMERS; CARRIERS; ENE;

D O I：

10.1039/c3cc49704f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introducing multiple reactive functional groups at the periphery of dendrimer materials presents considerable challenges if the functionality is able to self-react. An efficient and facile approach to introducing masked thiols at the surface of polyester dendrimers is presented. One-pot, deprotection/thiol-acrylate Michael addition from the xanthate-functional dendritic substrates (generation zero to two) has been achieved for the first time, with high efficiency demonstrated using three acrylates of varying chemistry and avoiding disulfide formation.

引用

页码：6574 / 6577

页数：4

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