Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

被引：9

作者：

D'Errico, Stefano ^{[1
]}

Oliviero, Giorgia ^{[1
]}

Borbone, Nicola ^{[1
]}

Piccialli, Vincenzo ^{[2
]}

Pinto, Brunella ^{[1
]}

De Falco, Francesca ^{[1
]}

Maiuri, Maria Chiara ^{[1
,3
]}

Carnuccio, Rosa ^{[1
]}

Costantino, Valeria ^{[1
]}

Nici, Fabrizia ^{[1
]}

Piccialli, Gennaro ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Sci Chim, I-80126 Naples, Italy

[3] INSERM, U848, IGR, F-94805 Villejuif, France

来源：

MOLECULES | 2014年 / 19卷 / 07期

关键词：

platinum complexes; nucleosides; cisplatin; chemotherapy; SOLID-PHASE SYNTHESIS; DNA-BINDING; COMPLEXES; CISPLATIN; CYTOTOXICITY; ANALOGS; RIBOSE; REACTIVITY; LIGANDS; DESIGN;

D O I：

10.3390/molecules19079339

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of four novel platinum complexes, bearing N-6-(6-aminohexyl) adenosine or a 1,6-di(adenosin-N-6-yl)-hexane respectively, as ligands of monofunctional cisplatin or monochloro(ethylendiamine) platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.

引用

页码：9339 / 9353

页数：15

共 49 条

[1] Platinum group antitumor chemistry: Design and development of new anticancer drugs complementary to cisplatin [J].