Short- and medium-term prognosis of Takotsubo syndrome in a Portuguese population

被引：19

作者：

Bento, Dina ^{[1
,2
]}

Azevedo, Olga ^{[3
]}

Santos, Rui ^{[4
]}

Almeida, Ana ^{[5
]}

Domingues, Kevin ^{[6
]}

Marmelo, Bruno ^{[7
]}

Reis, Liliana ^{[8
]}

Ruivo, Catarina ^{[9
]}

Guerreiro, Rui ^{[10
]}

Lima, Rui ^{[11
]}

Faria, Ricardo ^{[3
]}

Marreiros, Ana ^{[2
,12
]}

Marques, Nuno ^{[1
,2
,12
]}

Marques, Ana ^{[5
]}

Pereira, Ana ^{[5
]}

Pereira, Andreia ^{[13
]}

Faria, Bebiana ^{[3
]}

Picarra, Bruno ^{[10
]}

Negrier, Carolina ^{[8
]}

Gomes, Catarina ^{[5
]}

Cordeiro, Clara ^{[2
,12
]}

Silva, Daniela ^{[1
,2
]}

Moreira, Davide ^{[7
]}

Correia, Emanuel ^{[7
]}

Sa, Fernando ^{[8
]}

Antunes, Hugo ^{[7
]}

Cruz, Ines ^{[5
]}

Chin, Joana ^{[14
]}

Silva, Joana ^{[8
]}

Bispo, Joao ^{[1
,2
]}

Guedes, Joao ^{[1
,2
]}

Portugues, Joao ^{[3
]}

Pereira, Julio ^{[7
]}

Calvo, Lucy ^{[3
]}

Abreu, Luis ^{[7
]}

Lopes, Luis ^{[5
]}

Morais, Luis ^{[15
]}

Puga, Luis ^{[8
]}

Goncalves, Luisa ^{[7
]}

Oliveira, Margarida ^{[3
]}

Vieira, Maria ^{[6
]}

Neto, Micaela ^{[13
]}

Alves, Miguel ^{[6
]}

Craveiro, Nuno ^{[8
]}

Azevedo, Pedro ^{[1
,2
]}

Daniel, Pedro ^{[5
]}

Magalhaes, Pedro ^{[16
]}

von Hafe, Pedro ^{[3
]}

Gomes, Renata ^{[17
]}

Teixeira, Rogerio ^{[8
]}

机构：

[1] Ctr Hosp Univ Algarve Faro, Cardiol Dept, Faro, Portugal

[2] Algarve Biomed Ctr, Faro, Portugal

[3] Hosp Senhora da Oliveira, Cardiol Dept, Guimaraes, Portugal

[4] Ctr Hosp Tamega & Sousa, Cardiol Dept, Penafiel, Portugal

[5] Hosp Garcia da Orta, Cardiol Dept, Almada, Portugal

[6] Hosp Santarem, Cardiol Dept, Santarem, Portugal

[7] Ctr Hosp Tondela Viseu, Cardiol Dept, Viseu, Portugal

[8] Ctr Hosp & Univ Coimbra, Cardiol Dept, Coimbra, Portugal

[9] Ctr Hosp Leiria, Cardiol Dept, Leiria, Portugal

[10] Hosp Espirito Santo, Cardiol Dept, Evora, Portugal

[11] Unidade Local Saude Alto Minho, Cardiol Dept, Viana Do Castelo, Portugal

[12] Univ Algarve, Dept Ciencias Biomed & Med, Faro, Portugal

[13] Hosp Dr Nelio Mendonca, Cardiol Dept, Funchal, Portugal

[14] Ctr Hosp Barreiro Montijo, Cardiol Dept, Montijo, Portugal

[15] Ctr Hosp Lisboa Cent, Hosp Santa Marta, Cardiol Dept, Lisbon, Portugal

[16] Ctr Hosp Tras Os Montes & Alto Douro, Cardiol Dept, Vila Real, Portugal

[17] Hosp Santo Espirito Ilha Terceira, Cardiol Dept, Angra Do Heroismo, Portugal

来源：

REVISTA PORTUGUESA DE CARDIOLOGIA | 2019年 / 38卷 / 05期

关键词：

Takotsubo syndrome; Complications; Mortality; Prognosis; Follow-up; IN-HOSPITAL MORTALITY; APICAL BALLOONING SYNDROME; TAKO-TSUBO CARDIOMYOPATHY; CLINICAL-FEATURES; HEART-FAILURE; STRESS CARDIOMYOPATHY; NATURAL-HISTORY; QT PROLONGATION; OUTCOMES; PREDICTORS;

D O I：

10.1016/j.repc.2018.07.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Takotsubo syndrome (TTS) is characterized by transient left ventricular (LV) systolic dysfunction. Aim: To characterize a Portuguese population with TTS and to determine their short- and medium-term prognosis. Methods: We conducted a multicenter study in Portuguese hospitals that included all patients diagnosed with TTS, initially retrospectively and subsequently prospectively. Short- and medium-term clinical complications and mortality were assessed. Independent predictors of in-hospital complications and prognostic factors were determined. Results: A total of 234 patients (210 female, age 68 +/- 12 years) were included. During hospitalization, 32.9% of patients had complications: acute heart failure (24.4%), atrial fibrillation (9.0%), ventricular arrhythmias (2.6%), complete atrioventricular block (2.1%), stroke/transient ischemic attack (1.7%), and LV thrombus (1.3%). Chronic kidney disease (CKD) (p=0.02), coronary artery disease (CAD) (p=0.027), lower LV ejection fraction (LVEF) on admission (p=0.003), and dyspnea at presentation (p=0.019) were predictors of in-hospital complications. In-hospital mortality was 2.2%. At the mean follow-up of 33 +/- 33 months, all-cause mortality was 4.4%, cardiovascular mortality was 0.9% and TTS recurrence was 4.4%. Prolonged QTc interval on admission was associated with complications in follow-up (p=0.001). Conclusion: TTS has a good short- and medium-term prognosis. However, the rate of in-hospital complications is high and should not be overlooked. Dyspnea at presentation, CKD, CAD and lower LVEF on admission were independent predictors of in-hospital complications. Prolonged QTc on admission was associated with complications in follow-up. (C) 2019 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：349 / 357

页数：9

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