Statins and Risk of Cholangiocarcinoma: A Systematic Review and Meta-analysis

被引：4

作者：

Wijarnpreecha, Karn ^{[1
]}

Aby, Elizabeth S. ^{[2
]}

Ghoz, Hassan ^{[1
]}

Cheungpasitporn, Wisit ^{[3
]}

Lukens, Frank J. ^{[1
]}

Harnois, Denise M. ^{[1
]}

Ungprasert, Patompong ^{[4
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Coll Med, Jacksonville, FL USA

[2] Univ Minnesota, Div Gastroenterol & Hepatol, Minneapolis, MN USA

[3] Univ Mississippi, Dept Med, Div Nephrol, Med Ctr, Jackson, MS USA

[4] Cleveland Clin, Dept Rheumat & Immunol Dis, Cleveland, OH USA

来源：

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | 2020年 / 29卷 / 04期

关键词：

statins; bile duct cancer; biliary tract cancer; cholangiocarcinoma; meta-analysis; BILIARY-TRACT CANCERS; INTRAHEPATIC CHOLANGIOCARCINOMA; METABOLIC SYNDROME; UNITED-STATES; DIAGNOSIS; PATHOGENESIS; SIMVASTATIN; APOPTOSIS; MORTALITY; RECEPTOR;

D O I：

10.15403/jgld-2990

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: The use of statins has been shown to be associated with a decreased risk of cholangiocarcinoma (CCA) in many studies although the results have been inconsistent. We conducted this systematic review and meta-analysis to further investigate this possible association by identifying all relevant studies and combining their results together. Methods: A comprehensive literature review was conducted utilizing the MEDIA NE and EMBASE databases through March 2020 to identify all studies that compared the risk of CCA among individuals who use statins with individuals who do not use statins. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of seven studies with 6,251,187 participants fulfilled the eligibility criteria and were included in this meta-analysis. The pooled analysis found a significantly decreased risk of CCA among individuals who use statins compared with individuals who do not use statins with the pooled odds ratio of 0.68 (95% CI: 0.52-0.89; 12 96%). Conclusions: The current systematic review and meta-analysis found a significant association between the use of statins and a decreased risk of CCA.

引用

页码：629 / 635

页数：7

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