Plasma Plasminogen Activator Inhibitor-1 (PAI-1) Levels in Breast Cancer - Relationship with Clinical Outcome

被引:2
作者
Ferroni, Patrizia [1 ]
Roselli, Mario [2 ]
Portarena, Ilaria [2 ]
Formica, Vincenzo [2 ]
Riondino, Silvia [2 ]
La Farina, Francesca [3 ]
Costarelli, Leopoldo [4 ]
Melino, Antonia [1 ]
Massimiani, Gioia [2 ]
Cavaliere, Francesco [5 ]
Palmirotta, Raffaele [1 ]
Guadagni, Fiorella [1 ]
机构
[1] Hospitalizat & Hlth Care IRCCS San Raffaele Pisan, Sci Inst Res, Biomarker Discovery & Adv Technol BioDAT Lab, I-00163 Rome, Italy
[2] Univ Roma Tor Vergata, Tor Vergata Clin Ctr, Dept Syst Med, Rome, Italy
[3] Ceglie Messap Hosp, San Raffaele Fdn, Ceglie Messapica, Italy
[4] San Giovanni Hosp, Dept Pathol, Rome, Italy
[5] San Giovanni Hosp, Dept Surg, Rome, Italy
关键词
Plasminogen activator inhibitor-1; D-dimer; breast cancer; relapse-free survival; overall survival; PROSPECTIVE MULTICENTER; ADJUVANT CHEMOTHERAPY; AMERICAN SOCIETY; BIOMARKERS UPA; HIGH-RISK; D-DIMER; SYSTEM; UPA/PAI-1; RECEPTOR; THERAPY;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Signaling pathways triggered by increased thrombin or plasminogen activator inhibitor-1 (PAI-1) expression. drastically alter the tumor microenvironment, contributing to an adverse outcome. This study aimed to evaluate the prognostic value of coagulation/fibrinolytic activities in breast cancer (BC). Materials and Methods: Coagulation/fibrinolytic activities were investigated in 187 patients with breast cancer, with respect to possible associations with clinicopathological features and survival outcomes. Results: Levels of plasma PAI-1 (p<0.001), D-dimer (p=0.037) and activated protein C-dependent thrombin generation (p=0.003) were higher in women with breast cancer compared to 187 healthy women. PAI-1 directly correlated with D-dimer levels (p=0.009) and Ki67 expression (p=0.027), which were both predictors of elevated PAI-1 levels at multivariate regression analysis. Cox analysis demonstrated that an elevated plasma PAI-1 level had a negative prognostic impact in terms of relapse-free (hazard ratio=2.5, p=0.021) and overall survival (hazard ratio=2.7, p=0.002). Conclusion: Determination of plasma PAI-1 levels might provide important prognostic information in risk stratification and survival outcomes for patients with breast cancer.
引用
收藏
页码:1153 / 1161
页数:9
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