Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones

被引：17

作者：

Chen, Jiuxi ^{[1
,2
]}

Li, Jianjun ^{[1
]}

Su, Weike ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

MOLECULES | 2014年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

palladium; 2-aminobenzonitriles; arylsulfinates; o-aminobenzophenones; ALIPHATIC NITRILES SYNTHESIS; ALKYL ARYL KETONES; ARYLBORONIC ACIDS; ALDEHYDES; ARYLATION; EFFICIENT; DERIVATIVES; ARYLKETONES; CHLORIDES; AGENTS;

D O I：

10.3390/molecules19056439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.

引用

页码：6439 / 6449

页数：11

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