Immune regulation of bone loss by Th17 cells

被引：67

作者：

Adamopoulos, Iannis E. ^{[1
]}

Bowman, Edward P. ^{[1
]}

机构：

[1] Schering Plough Biopharma, Dept Immunol, Palo Alto, CA 94304 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1186/ar2502

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

引用

页数：9

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