Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor

被引：24

作者：

Pearce, SHS

机构：

[1] Univ Newcastle Upon Tyne, Int Ctr Life, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[2] Univ Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

ANNALS OF MEDICINE | 2002年 / 34卷 / 03期

关键词：

calcium sensing receptor; hypercalcaemia; hypocalcaemia; parathyroid;

D O I：

10.1080/713782140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The calcium-sensing receptor is a 6 protein-coupled receptor that has a key role in extracellular calcium homeostasis, regulating the secretion of parathyroid hormone and the reabsorption of urinary calcium appropriate to the prevailing calcaemic environment. Molecular abnormalities of the calcium-sensing receptor are responsible for three clinical disorders, familial benign hypocalciuric hypercalcaemia, neonatal severe hyperparathyroidism and autosomal dominant hypocalcaemia with hypercalciuria. In the future, therapeutic compounds that modulate calcium-sensing receptor function may have a role in the medical management of hyperparathyroidism (calcimimetic drugs) and osteoporosis (calcilytic drugs).

引用

页码：201 / 206

页数：6

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