Keap1 as the redox sensor of the antioxidant response

被引：91

作者：

Sihvola, Virve ^{[1
]}

Levonen, Anna-Liisa ^{[1
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Neulaniementie 2, FIN-70211 Kuopio, Finland

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 617卷

基金：

芬兰科学院;

关键词：

Thiol; Nrf2; Reactive oxygen species; Electrophile; OXIDATIVE STRESS-RESPONSE; PROTEASOMAL DEGRADATION; NRF2; UBIQUITINATION; CYSTEINE RESIDUES; SULFHYDRYL-GROUPS; PHASE-2; RESPONSE; NITRIC-OXIDE; DLG MOTIFS; E3; LIGASE; ACTIVATION;

D O I：

10.1016/j.abb.2016.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) and products of their reactions with cellular macromolecules such as unsaturated fatty acids have been implicated to be important regulators of signalling processes via oxidation or allcylation of redox active thiol residues in target proteins. One of key redox-sensitive signalling proteins mediating the response to oxidant stress is Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1), which is a negative regulator of transcription factor Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and the central hub for sensing endogenous and environmental oxidative and electrophilic stress. In this review, we provide an overview of the mechanisms by which Keap1 orchestrates the antioxidant response and how the system can be targeted for therapy. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：94 / 100

页数：7

共 86 条

[1] Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling [J].

Adam, Julie ;

Hatipoglu, Emine ;

O'Flaherty, Linda ;

Ternette, Nicola ;

Sahgal, Natasha ;

Lockstone, Helen ;

Baban, Dilair ;

Nye, Emma ;

Stamp, Gordon W. ;

Wolhuter, Kathryn ;

Stevens, Marcus ;

Fischer, Roman ;

Carmeliet, Peter ;

Maxwell, Patrick H. ;

Pugh, Chris W. ;

Frizzell, Norma ;

Soga, Tomoyoshi ;

Kessler, Benedikt M. ;

El-Bahrawy, Mona ;

Ratcliffe, Peter J. ;

Pollard, Patrick J. .

CANCER CELL, 2011, 20 (04) :524-537

[2]

ALBAGLI O, 1995, CELL GROWTH DIFFER, V6, P1193

[3]

Baird L., 2013, DIFFUSION DYNAMICS K

[4] Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element [J].

Balogun, E ;

Hoque, M ;

Gong, PF ;

Killeen, E ;

Green, CJ ;

Foresti, R ;

Alam, J ;

Motterlini, R .

BIOCHEMICAL JOURNAL, 2003, 371 :887-895

[5] Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro [J].

Brennan, Melanie S. ;

Matos, Maria F. ;

Li, Bing ;

Hronowski, Xiaoping ;

Gao, Benbo ;

Juhasz, Peter ;

Rhodes, Kenneth J. ;

Scannevin, Robert H. .

PLOS ONE, 2015, 10 (03)

[6] Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein [J].

Camp, Nathan D. ;

James, Richard G. ;

Dawson, David W. ;

Yan, Feng ;

Davison, James M. ;

Houck, Scott A. ;

Tang, Xiaobo ;

Zheng, Ning ;

Major, Michael B. ;

Moon, Randall T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (09) :6539-6550

[7] Structural basis of Keap1 interactions with Nrf2 [J].

Canning, Peter ;

Sorrell, Fiona J. ;

Bullock, Alex N. .

FREE RADICAL BIOLOGY AND MEDICINE, 2015, 88 :101-107

[8] Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response [J].

Chen, Weimin ;

Sun, Zheng ;

Wang, Xiao-Jun ;

Jiang, Tao ;

Huang, Zheping ;

Fang, Deyu ;

Zhang, Donna D. .

MOLECULAR CELL, 2009, 34 (06) :663-673

[9] Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity [J].

Chowdhry, S. ;

Zhang, Y. ;

McMahon, M. ;

Sutherland, C. ;

Cuadrado, A. ;

Hayes, J. D. .

ONCOGENE, 2013, 32 (32) :3765-3781

[10] NRF2 regulates serine biosynthesis in non-small cell lung cancer [J].

DeNicola, Gina M. ;

Chen, Pei-Hsuan ;

Mullarky, Edouard ;

Sudderth, Jessica A. ;

Hu, Zeping ;

Wu, David ;

Tang, Hao ;

Xie, Yang ;

Asara, John M. ;

Huffman, Kenneth E. ;

Wistuba, Ignacio I. ;

Minna, John D. ;

DeBerardinis, Ralph J. ;

Cantley, Lewis C. .

NATURE GENETICS, 2015, 47 (12) :1475-+

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