Phosphatidylserine-mediated phagocytosis of anticancer drug-treated cells by macrophages

被引：26

作者：

Shiratsuchi, A ^{[1
]}

Nakanishi, Y ^{[1
]}

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 920, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 1999年 / 126卷 / 06期

关键词：

anticancer drug; apoptosis; phagocytosis; phosphatidylserine;

D O I：

10.1093/oxfordjournals.jbchem.a022555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptotic cells are rapidly phagocytosed and eliminated from the organism. Although cancer cells apoptose when treated with anticancer drugs, how those cells are recognized by phagocytic cells has remained unclear. The human leukemia cell line Jurkat was cultured with doxorubicin or bufalin and induced to undergo apoptosis accompanied by phosphatidylserine externalization, When apoptotic Jurkat cells were mixed with mouse peritoneal macrophages, efficient phagocytosis was observed. Apoptosis and phagocytosis of Jurkat cells were both inhibited by Z-VAD-FMK, and phagocytosis was significantly reduced in the presence of phosphatidylserine-containing liposomes. These results suggest that anticancer drugs induce apoptosis-dependent and phosphatidylserine-mediated phagocytosis in cancer cells.

引用

页码：1101 / 1106

页数：6

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