Prevalence and disease association of hepatitis G virus infection in Japan

被引:90
作者
Nakatsuji, Y
Shih, JWK
Tanaka, E
Kiyosawa, K
Wages, J
Kim, JP
Alter, HJ
机构
[1] NIH, DEPT TRANSFUS MED, BETHESDA, MD 20852 USA
[2] SHINSHU UNIV, SCH MED, DEPT INTERNAL MED 2, MATSUMOTO, NAGANO 390, JAPAN
[3] GENELABS TECHNOL INC, REDWOOD CITY, CA USA
关键词
dual viral infection; hepatitis G virus; non A-E hepatitis; parenteral transmission; quantification HGV RNA; RT-PCR;
D O I
10.1111/j.1365-2893.1996.tb00103.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A reverse transcriptase-polymerase chain reaction procedure (RT-PCR) for the detection of hepatitis G virus (HGV) RNA was used to examine the prevalence of HGV infection and HGV-related disease in Japan. Among 48 patients with acute non-A, B, C, D, E (non-A-E) hepatitis (five transfusion-associated cases and 43 sporadic cases), only one patient (2%), a transfusion recipient, was HGV RNA positive. Similarly, among 50 patients with established chronic non-A-E hepatitis, only two (4%) were positive for HGV RNA. These frequencies were not significantly different from those in 129 voluntary blood donors (0.8%). By contrast, HGV infection was relatively common among patients who were also infected with other hepatitis viruses. HGV co-infection or superinfection was found in seven of 53 (13%) patients with acute hepatitis C, in 15 of 126 (12%) patients with chronic hepatitis C, in three of 21 (14%) patients with acute hepatitis B and in four of 81 (5%) patients with chronic hepatitis B. Among the 29 dually infected patients, 15 (52%) had a history of blood transfusion. HGV was also detected in seven (10%) of 69 haemodialysis patients, of whom only one had a dual infection with hepatitis C virus (HCV) and an elevated aminotransferase level. In conclusion: HGV RNA was found in only a low percentage of patients with either acute or chronic non-A-E hepatitis; HGV appears toco-infect or superinfect in 10-15% of HCV infections and in 5-15% of HBV infections; the prevalence of HGV infection (0.8%) among voluntary blood donors in Japan is similar to that for HCV infection; a history of blood transfusion was obtained in 22 (55%) of the total 40 HGV-positive subjects; and isolated HGV infection appears to have a low disease burden.
引用
收藏
页码:307 / 316
页数:10
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