Structural and genetic diversity in antibody repertoires from diverse species

被引：55

作者：

de Los Rios, Miguel ^{[1
]}

Criscitiello, Michael F. ^{[2
]}

Smider, Vaughn V. ^{[3
]}

机构：

[1] Fabrus Inc, Div Sev Therapeut, San Diego, CA 92121 USA

[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX 77843 USA

[3] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2015年 / 33卷

关键词：

HEAVY-CHAIN ANTIBODIES; SINGLE-DOMAIN ANTIBODIES; PHYLOGENETICALLY PRIMITIVE VERTEBRATE; COMPLEMENTARITY-DETERMINING REGIONS; CHICKEN IMMUNOGLOBULIN GENES; VIVO AFFINITY MATURATION; BOVINE IGM ANTIBODIES; V-H FAMILY; ANTIGEN RECEPTOR; PHAGE-DISPLAY;

D O I：

10.1016/j.sbi.2015.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody repertoires may enable discovery or engineering of antibodies from these non-human species against difficult or important epitopes.

引用

页码：27 / 41

页数：15

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