Entry of hepatitis B and C viruses - recent progress and future impact

被引：46
作者：
Baumert, Thomas F. [1 ,2 ]
Meredith, Luke [3 ]
Ni, Yi [4 ]
Felmlee, Daniel J. [1 ,2 ]
McKeating, Jane A. [3 ]
Urban, Stephan [4 ]
机构：
[1] Univ Strasbourg, INSERM, U1110, F-67000 Strasbourg, France
[2] Strasbourg Univ Hosp, Ctr Liver & Digest Dis, F-67000 Strasbourg, France
[3] Univ Birmingham, NIHR Ctr Liver Dis, Ctr Human Virol, Birmingham B15 2TT, W Midlands, England
[4] Univ Heidelberg Hosp, Dept Infect Dis, D-69120 Heidelberg, Germany
来源：
CURRENT OPINION IN VIROLOGY | 2014年 / 4卷
关键词：
LARGE SURFACE PROTEIN; ENVELOPE PROTEIN; NEUTRALIZING ANTIBODIES; INFECTION; RECEPTOR; BINDING; DETERMINANTS; REQUIRES; CD81; IDENTIFICATION;
D O I：
10.1016/j.coviro.2013.12.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.
引用
收藏
页码：58 / 65
页数：8
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