Current and Potential Biologic Drugs for the Treatment of Chronic Urticaria

被引：9

作者：

Sanchez-Borges, Mario ^{[1
,2
]}

Gonzalez Diaz, Sandra ^{[3
,4
]}

Antonio Ortega-Martell, Jose ^{[5
]}

Isabel Rojo, Maria ^{[6
]}

Ansotegui, Ignacio J. ^{[7
]}

机构：

[1] Ctr Med Docente Trinidad, Allergy & Clin Immunol Dept, Caracas, Venezuela

[2] Clin Avila, Allergy & Clin Immunol Dept, Caracas, Venezuela

[3] Univ Autonoma Nuevo Leon, Ctr Reg Excelencia CONACYT WAO Alergia Asma & Imm, Hosp Univ, Fac Med, Monterrey, Nuevo Leon, Mexico

[4] San Francisco Ctr Especialistas Med, San Francisco, CA USA

[5] Univ Autonoma Estado Hidalgo, Articulo 27 102 Col Constituc, Pachuca 27102, Hidalgo, Mexico

[6] Juarez Hosp, Allergy Serv, Mexico City, DF, Mexico

[7] Hosp Quironsalud Bizkaia, Dept Allergy & Immunol, Carretera Leioa Unbe 33 Bis, Erandio Bilbao 48950, Spain

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2020年 / 40卷 / 04期

关键词：

Angioedema; Biologics; Chronic urticaria; Omalizumab; DOSE INTRAVENOUS IMMUNOGLOBULIN; RECEPTOR ANTAGONIST ANAKINRA; CHRONIC AUTOIMMUNE URTICARIA; QUALITY-OF-LIFE; SCHNITZLERS SYNDROME; OMALIZUMAB; IGE; EFFICACY; LIGELIZUMAB; SAFETY;

D O I：

10.1016/j.iac.2020.06.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This article reviews biologic treatments that are currently applied for the treatment of severe chronic urticaria. Monoclonal anti–immunoglobulin E (omalizumab) is effective and safe in many patients, but accessibility and cost constitute barriers to its wider use. Questions on the optimal duration of the treatment and possible symptom recurrences after discontinuing the drug are still raised. A discussion is presented about several other biologics currently under investigation with potential to be incorporated in the near future in patients with severe chronic urticaria. © 2020 Elsevier Inc.

引用

页码：609 / 623

页数：15

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