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The who, how and where of antigen presentation to B cells
被引:502
作者:
Batista, Facundo D.
[1
]
Harwood, Naomi E.
[1
]
机构:
[1] Canc Res UK London Res Inst, Lymphocyte Interact Lab, Lincolns Inn Fields Labs, London WC2A 3PX, England
关键词:
FOLLICULAR DENDRITIC CELLS;
HUMORAL IMMUNE-RESPONSE;
SPLENIC MARGINAL ZONE;
LYMPH-NODE FOLLICLES;
IN-VIVO;
SUBCAPSULAR SINUS;
ANTIBODY-RESPONSES;
SOLUBLE-ANTIGEN;
T-CELLS;
RECEPTOR MICROCLUSTERS;
D O I:
10.1038/nri2454
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
A functional immune system depends on the appropriate activation of lymphocytes following antigen encounter. In this Review, we summarize studies that have used high-resolution imaging approaches to visualize antigen presentation to B cells in secondary lymphoid organs. These studies illustrate that encounters of B cells with antigen in these organs can be facilitated by diffusion of the antigen or by the presentation of antigen by macrophages, dendritic cells and follicular dendritic cells. We describe cell-surface molecules that might be important in mediating antigen presentation to B cells and also highlight the key role of B cells themselves in antigen transport. Data obtained from the studies discussed here highlight the predominance, importance and variety of the cell-mediated processes that are involved in presenting antigen to B cells in vivo.
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页码:15 / 27
页数:13
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