Regioselective synthesis of 9-substituted-8-azaguanines (5-amino-3-substituted-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one)

被引：8

作者：

Sznaidman, ML

Beauchamp, LM

机构：

[1] Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 06期

关键词：

D O I：

10.1002/jhet.5570330609

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By modifying previously described methods for the synthesis of 9-substituted-guanines from imidazoles, we have developed a new procedure for the regioselective synthesis of 9-substituted-8-azaguanines (5-amino-3-substituted-3,6-dihydro-7H-1,2,3-triazolo[4,5-djpyrimidin-7-one) from triazoles in high yields. The method seems suitable for the introduction of a variety of substituents including sugars, carbocyclic, acyclic and carboacyclic chains.

引用

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页码：1605 / 1610

页数：6

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