Experimental Determination and Thermodynamic Models for Solid-Liquid Equilibrium of 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide in Pure and Binary Solvent Mixtures for T = (278.15-328.15) K

被引：12

作者：

Sheng, Huace ^{[1
]}

Fan, Shimin ^{[2
]}

Zhao, Wangdan ^{[1
]}

Zhang, Jian ^{[1
]}

Zhao, Xinxin ^{[1
]}

Hu, Yonghong ^{[1
,2
]}

Qian, Yonggen ^{[3
]}

Yang, Wenge ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Tech Univ, Synerget Innovat Ctr Adv Mat, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

[3] Jiangsu Fengyuan Biol Engn Co Ltd, 6 Hongqi Rd, Sheyang Xian 224300, Jiangsu Sheng, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2018年 / 63卷 / 06期

基金：

中国国家自然科学基金;

关键词：

11; ORGANIC-SOLVENTS; PLUS ETHYL-ACETATE; SOLUBILITY DETERMINATION; HEPATOCELLULAR-CARCINOMA; SORAFENIB DERIVATIVES; MIXING PROPERTIES; MIXED-SOLVENTS; N-BUTANOL; ACID; TEMPERATURES;

D O I：

10.1021/acs.jced.8b00165

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

In this study, the solubility of 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide (APMC) in pure tetrahydrofuran, ethyl acetate, acetonitrile, n-butanol, n-propanol, ethanol, methanol, and three binary solvent mixtures (ethyl acetate + methanol, ethyl acetate + ethanol, and ethyl acetate + n-butanol) was first experimentally determined within the temperature range from (278.15 to 328.15) K under atmosphere pressure by the gravimetric method. The results reveal that the solubility of APMC increases with an increase in temperature in all of the solvents selected. The modified Apelblat equation and the Buchowski-Ksiazaczak Ah equation were used to correlate the experimental solubility in pure solvents while the modified Apelblat equation, the CNIBS/R-K model, and the Jouyban-Acree model were applied to correlate the solubility in binary solvent mixtures. All of the models could be well applied, and the modified Apelblat equation stood out to be more suitable with a higher accuracy compared to that of the other three models.

引用

页码：2185 / 2196

页数：12

共 58 条

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