Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series

被引：18

作者：

Bernard-Valnet, Raphael ^{[1
,2
,3
,4
]}

Cobo-Calvo, Alvaro ^{[5
,6
,7
]}

Siegfried, Aurore ^{[8
]}

Marasescu, Raluca ^{[9
]}

Bonnan, Mickael ^{[9
]}

Ballan, Guillaume ^{[10
]}

Ellie, Emmanuel ^{[10
]}

Bauer, Jan ^{[11
]}

Uro-Coste, Emmanuelle ^{[8
]}

Marignier, Romain ^{[5
,6
,7
]}

Brassat, David ^{[1
,2
]}

机构：

[1] Univ Toulouse III, Ctr Pathophysiol Toulouse Purpan, INSERM, U1043,CNRS 5282, F-31024 Toulouse, France

[2] CHU Toulouse, CRC SEP, Pole Neurosci, F-31059 Toulouse, France

[3] CHU Vaudois, Dept Neurosci, CH-1011 Lausanne, Switzerland

[4] CHU Vaudois, Dept Med, CH-1011 Lausanne, Switzerland

[5] Pierre Wertheimer Hosp Civils Lyon, Serv Neurol Sclerose Plaques Pathol Myeline & Neu, F-6977 Lyon, France

[6] Pierre Wertheimer Hosp Civils Lyon, Ctr Reference Malad Inflammatoires Rares Cerveau, F-6977 Lyon, France

[7] CNRS, Lyons Neurosci Res Ctr, U1028, INSERM,UMR5292,CNRS,FLUID Team, F-69008 Lyon, France

[8] CHU Toulouse, IUCT Oncopole, Serv Anatomopathol, Toulouse, France

[9] CH Pau, Serv Neurol, F-64000 Pau, France

[10] CH Cote Basque, Serv Neurol, F-64109 Bayonne, France

[11] Med Univ Vienna, Ctr Brain Res, Vienna, Austria

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 31卷

关键词：

Demyelinating diseases; Neuromyelitis optica; Autoimmune diseases; Paraneoplastic syndromes; Ovarian teratoma;

D O I：

10.1016/j.msard.2019.03.031

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Pathological analysis of teratomas revealed glial component strongly expressing AQP4 and closely localized to immune infiltrates. Our series highlight the rare association of teratoma with NMOSD and the possible paraneoplastic mechanism.

引用

页码：97 / 100

页数：4

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