Adrenomedullin and non-dipping circadian pattern in newly diagnosed essential hypertension

被引:6
作者
Yucel, O. [1 ,2 ]
Gunes, H. [1 ,3 ]
Kerkutluoglu, M. [1 ,3 ]
Ozturk, B. [1 ,3 ]
Kirisci, M. [1 ,4 ]
Alkan, Baylan F. [1 ,5 ]
机构
[1] Kahramanmaras Sutcu Imam Univ, Fac Med, Dept Cardiol, Kahramanmaras, Turkey
[2] Near East Univ, Dept Cardiol, Nicosia, Turkey
[3] Kahramanmaras Sutcu Imam Univ, Dept Cardiol, Kahramanmaras, Turkey
[4] Kahramanmaras Sutcu Imam Univ, Dept Cardiovasc Surg, Kahramanmaras, Turkey
[5] Kahramanmaras Sutcu Imam Univ, Dept Biochem, Kahramanmaras, Turkey
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2020年 / 121卷 / 12期
关键词
adrenomedullin; high-sensitivity C-reactive protein; dipper; non-dipper hypertension; NOCTURNAL BLOOD-PRESSURE; PLASMA ADRENOMEDULLIN; HYPOTENSIVE PEPTIDE; BRAIN-BARRIER; PROGRESSION; RELAXATION; EXPRESSION; PROGNOSIS; DISEASE; PROTEIN;
D O I
10.4149/BLL_2020_145
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: There is frequently a relationship between nocturnal hypertension and non-dipping pattern and endothelial dysfunction. Studies conducted previously have indicated that adrenomedullin (AM) (a potent, long-lasting, vasodilatory peptide) is capable of regulating endothelial cell function. The aim of the current research is to investigate the association between absolute night-time blood pressure (BP) and circadian BP pat tern with serum AM and high-sensitivity C-reactive protein (hsCRP) levels in cases in whom untreated arterial hypertension has been newly diagnosed. METHODS: Ambulatory BP monitoring was performed in 100 individuals with hypertension (50 dippers, 50 non-dippers) and 50 healthy controls for 24 hours. Measurement and recording of AM and hsCRP serum levels were performed. RESULTS: A strong correlation between night-time BP levels and AM and hsCRP levels was determined (p<0.001). On the contrary, higher AM levels were determined in the non-dipper group compared to the dipper and normotensive groups (non-dipper group, 258 +/- 27 pg/mL; dipper group, 199 +/- 30 pg/mL; normotensive group, 150 +/- 11 pg/mL; p<0.001). The non-dipper group exhibited significantly higher hsCRP levels in comparison with the remaining two groups (p=0.017). An independent association was determined between AM (p=0.014) and hsCRP (p=0.032) and a non-dipping pattern in a multivariate logistic regression analysis. CONCLUSIONS: The nocturnal hypertensive and non-dipper groups exhibited increased AM levels. An independent association was identified between AM and hsCRP and a non-dipping pattern. It is implied that increased AM levels in individuals with non-dipper hypertension may be related to a longer exposure time to high BP. The mentioned findings indicate a potential future part of AM in identifying patients with hypertension that are at higher risk of target organ damage (Tab. 3, Fig. 4, Ref. 41). Text in PDF www.elis.sk
引用
收藏
页码:881 / 887
页数:7
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