Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

被引：11

作者：

Hidaka, Masafumi ^{[1
]}

Kosaka, Keita ^{[1
]}

Tsushima, Saori ^{[1
]}

Uchida, Chiyoko ^{[2
]}

Takahashi, Katsuhiko ^{[3
]}

Takahashi, Noriko ^{[4
]}

Tsubuki, Masayoshi ^{[5
]}

Hara, Yukihiko ^{[6
]}

Uchida, Takafumi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Dept Mol Cell Sci, Mol Enzymol,Aoba Ku, 468-1 Aoba, Sendai, Miyagi 9800845, Japan

[2] Fukushima Univ, Dept Human Dev & Culture, Fukushima, Fukushima 9601296, Japan

[3] Hoshi Univ, Lab Biochem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan

[4] Hoshi Univ, Inst Med Chem, Lab Bioorgan Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan

[5] Hoshi Univ, Inst Med Chem, Lab Physiol Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan

[6] Hara Off Inc, Tea Solut, Sumida Ku, 1-18-15-510 Taihei, Tokyo 1300012, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 499卷 / 03期

关键词：

Food polyphenols; EGCG; Caffeic acid; Tannic acid; Prolyl isomerase; Pin1; CELL-CYCLE; INHIBITORS; DISEASE; CANCER; RISK; MICE; TEA;

D O I：

10.1016/j.bbrc.2018.03.212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases. (C) 2018 Elsevier Inc. All rights reserved.

引用

收藏

页码：681 / 687

页数：7

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