Regulation of glucose homoeostasis by brown adipose tissue

被引：97

作者：

Peirce, Vivian ^{[1
]}

Vidal-Puig, Antonio ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2013年 / 1卷 / 04期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

COLD-EXPOSURE REVERSES; ADULT HUMANS; INSULIN-RESISTANCE; ENERGY-EXPENDITURE; IN-VIVO; ADAPTIVE THERMOGENESIS; ADRENOCEPTOR AGONIST; PERIPHERAL-TISSUES; LIPID-METABOLISM; MESSENGER-RNA;

D O I：

10.1016/S2213-8587(13)70055-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brown adipose tissue (BAT) has emerged as a therapeutic target for the treatment of obesity. Activation of BAT in human beings could also have beneficial metabolic effects that might resolve common complications of obesity, such as type 2 diabetes, by ameliorating the glucolipotoxic pathological changes that underlie the development of peripheral insulin resistance and impaired insulin secretion due to pancreatic beta-cell failure. Evidence from rodent models suggests that BAT activation improves glucose homoeostasis through several mechanisms, which could point to new strategies to optimise stimulation of BAT in human beings and reverse insulin resistance in peripheral tissues.

引用

页码：353 / 360

页数：8

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