Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum

被引：81

作者：

Chan, KL ^{[1
]}

Choo, CY

Abdullah, NR

Ismail, Z

机构：

[1] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

[2] Inst Med Res, Herbal Med Res Ctr, Kuala Lumpur 50588, Malaysia

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 92卷 / 2-3期

关键词：

antimalarial activity; Plasmodium falciparum lactate dehydrogenase; cytotoxicity; Eurycoma longifolia; quassinoids; alkaloid;

D O I：

10.1016/j.jep.2004.02.025

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The roots of Eurycoma longifolia Jack have been used as traditional medicine to treat malaria. A systematic bioactivity-guided fractionation of this plant was conducted involving the determination of the effect of its various extracts and their chemical constituents on the lactate dehydrogenase activity of in vitro chloroquine-resistant Gombak A isolate and chloroquine-sensitive D10 strain of Plasmodium falciparum parasites. Their antiplasmodial activity was also compared with their known in vitro cytotoxicity against KB cells. Four quassinoids, eurycomanone (1), 13,21-dihydroeurycomanone (3), 13alpha(21)-epoxyeurycomanone (4), eurycomalactone (6) and an alkaloid, 9-methoxycanthin-6-one (7), displayed higher antiplasmodial activity against Gombak A isolate but were less active against the D10 strain when compared with chloroquine. Amongst the compounds tested, 1 and 3 showed higher selectivity indices obtained for the cytotoxicity to antiplasmodial activity ratio than 14,15beta-dihydroxyklaineanone (2), eurycomanol (5), 6 and 7. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：223 / 227

页数：5

共 14 条

[1] IN-VITRO ANTIMALARIAL ACTIVITY OF QUASSINOIDS FROM EURYCOMA-LONGIFOLIA AGAINST MALAYSIAN CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM ISOLATES [J].

ANG, HH ;

CHAN, KL ;

MAK, JW .

PLANTA MEDICA, 1995, 61 (02) :177-178

[2] A QUASSINOID GLYCOSIDE FROM THE ROOTS OF EURYCOMA-LONGIFOLIA [J].

CHAN, KL ;

LEE, SP ;

SAM, TW ;

HAN, BH .

PHYTOCHEMISTRY, 1989, 28 (10) :2857-2859

[3]

CHAN KL, 1986, PLANTA MED, V52, P105

[4]

Gimlette JD, 1977, DICT MALAYAN MED, P183

[5] In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia [J].

Jiwajinda, S ;

Santisopasri, V ;

Murakami, A ;

Kawanaka, M ;

Kawanaka, H ;

Gasquet, M ;

Eilas, R ;

Balansard, G ;

Ohigashi, H .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 82 (01) :55-58

[6] STUDIES ON INDONESIAN MEDICINAL-PLANTS .4. CYTOTOXIC AND ANTIMALARIAL CONSTITUENTS OF THE ROOTS OF EURYCOMA-LONGIFOLIA [J].

KARDONO, LBS ;

ANGERHOFER, CK ;

TSAURI, S ;

PADMAWINATA, K ;

PEZZUTO, JM ;

KINGHORN, AD .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05) :1360-1367

[7] MEASUREMENT OF THE LACTATE-DEHYDROGENASE ACTIVITY OF PLASMODIUM-FALCIPARUM AS AN ASSESSMENT OF PARASITEMIA [J].

MAKLER, MT ;

HINRICHS, DJ .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (02) :205-210

[8] PARASITE LACTATE-DEHYDROGENASE AS AN ASSAY FOR PLASMODIUM-FALCIPARUM DRUG-SENSITIVITY [J].

MAKLER, MT ;

RIES, JM ;

WILLIAMS, JA ;

BANCROFT, JE ;

PIPER, RC ;

GIBBINS, BL ;

HINRICHS, DJ .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (06) :739-741

[9] NEW QUASSINOIDS FROM THE ROOTS OF EURYCOMA-LONGIFOLIA [J].

MORITA, H ;

KISHI, E ;

TAKEYA, K ;

ITOKAWA, H ;

TANAKA, O .

CHEMISTRY LETTERS, 1990, (05) :749-752

[10] PLANTS AS SOURCES OF ANTIMALARIAL-DRUGS - INVITRO ANTIMALARIAL ACTIVITIES OF SOME QUASSINOIDS [J].

ONEILL, MJ ;

BRAY, DH ;

BOARDMAN, P ;

PHILLIPSON, JD ;

WARHURST, DC ;

PETERS, W ;

SUFFNESS, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (01) :101-104

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