The mycobiota: interactions between commensal fungi and the host immune system

被引：471

作者：

Underhill, David M. ^{[1
]}

Iliev, Iliyan D. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, F Widjaja Fdn, Inflammatory Bowel & Immunobiol Res Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MANNOSE-BINDING LECTIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS; VULVO-VAGINAL CANDIDIASIS; INNATE LYMPHOID-CELLS; DISTAL GUT MICROBIOTA; HELPER; 17; RESPONSES; ASPERGILLUS-FUMIGATUS; HUMAN SKIN; GENE POLYMORPHISMS; STAT1; MUTATIONS;

D O I：

10.1038/nri3684

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The body is host to a wide variety of microbial communities from which the immune system protects us and that are important for the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. Investigators have mostly focused on the bacterial members of these communities, but fungi are increasingly being recognized to have a role in defining these communities and to interact with immune cells. In this Review, we discuss what is currently known about the makeup of fungal communities in the body and the features of the immune system that are particularly important for interacting with fungi at these sites.

引用

页码：405 / 416

页数：12

共 50 条

[21] The effects of the microbiota on the host immune system [J].

Karczewski, Jacek ;

Poniedzialek, Barbara ;

Adamski, Zygmunt ;

Rzymski, Piotr .

AUTOIMMUNITY, 2014, 47 (08) :494-504

[22] Friend or foe: using systems biology to elucidate interactions between fungi and their hosts [J].

Rizzetto, Lisa ;

Cavalieri, Duccio .

TRENDS IN MICROBIOLOGY, 2011, 19 (10) :509-515

[23] Reciprocal Interactions between Commensal Bacteria and γδ Intraepithelial Lymphocytes during Mucosal Injury [J].

Ismail, Anisa S. ;

Behrendt, Cassie L. ;

Hooper, Lora V. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :3047-3054

[24] Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer [J].

Goc, Jeremy ;

Hepworth, Matthew R. ;

Sonnenberg, Gregory F. .

INTERNATIONAL IMMUNOLOGY, 2016, 28 (01) :43-52

[25] Recognition of Fungal Components by the Host Immune System [J].

Garcia-Carnero, Laura C. ;

Martinez-Alvarez, Jose A. ;

Salazar-Garcia, Luis M. ;

Lozoya-Perez, Nancy E. ;

Gonzalez-Hernandez, Sandra E. ;

Tamez-Castrellon, Alma K. .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2020, 21 (03) :245-264

[26] Host genetics of innate immune system in infection [J].

Hsu, Amy P. ;

Holland, Steven M. .

CURRENT OPINION IN IMMUNOLOGY, 2022, 74 :140-149

[27] Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system [J].

Peng, Guotao ;

Fadeel, Bengt .

ADVANCED DRUG DELIVERY REVIEWS, 2022, 188

[28] Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease [J].

Chen, Yongyan ;

Cui, Wenwen ;

Li, Xiao ;

Yang, Huan .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[29] Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment [J].

Misetic, Hrvoje ;

Keddar, Mohamed Reda ;

Jeannon, Jean-Pierre ;

Ciccarelli, Francesca D. D. .

GENOME MEDICINE, 2023, 15 (01)

[30] Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection [J].

Fanning, Saranna ;

Hall, Lindsay J. ;

Cronin, Michelle ;

Zomer, Aldert ;

MacSharry, John ;

Goulding, David ;

Motherway, Mary O'Connell ;

Shanahan, Fergus ;

Nally, Kenneth ;

Dougan, Gordon ;

van Sinderen, Douwe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (06) :2108-2113

← 1 2 3 4 5 →