The mycobiota: interactions between commensal fungi and the host immune system

被引：468
|
作者：
Underhill, David M. [1 ]
Iliev, Iliyan D. [1 ]
机构：
[1] Cedars Sinai Med Ctr, F Widjaja Fdn, Inflammatory Bowel & Immunobiol Res Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 06期
基金：
美国国家卫生研究院;
关键词：
MANNOSE-BINDING LECTIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS; VULVO-VAGINAL CANDIDIASIS; INNATE LYMPHOID-CELLS; DISTAL GUT MICROBIOTA; HELPER; 17; RESPONSES; ASPERGILLUS-FUMIGATUS; HUMAN SKIN; GENE POLYMORPHISMS; STAT1; MUTATIONS;
D O I：
10.1038/nri3684
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The body is host to a wide variety of microbial communities from which the immune system protects us and that are important for the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. Investigators have mostly focused on the bacterial members of these communities, but fungi are increasingly being recognized to have a role in defining these communities and to interact with immune cells. In this Review, we discuss what is currently known about the makeup of fungal communities in the body and the features of the immune system that are particularly important for interacting with fungi at these sites.
引用
收藏
页码：405 / 416
页数：12
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