Nanoparticle-based diagnosis and therapy

被引：115

作者：

Groneberg, David A.

Giersig, Michael

Welte, Tobias

Pison, Ulrich

机构：

[1] Univ Med Berlin, Klin Anasthesiol & Operat Intensivmed, Standort Westend Klinikum Spandauer Damm 130, D-14050 Berlin, Germany

[2] Hannover Med Sch, Dept Resp Med, D-30625 Hannover, Germany

[3] Free Univ Berlin, Charite Sch Med, Otto Heubner Ctr, D-13353 Berlin, Germany

[4] Humboldt Univ, D-13353 Berlin, Germany

[5] Ctr Adv European Studies & Res Stiftung Ca E S Ar, D-53175 Bonn, Germany

来源：

CURRENT DRUG TARGETS | 2006年 / 7卷 / 06期

关键词：

nanotechnology; nanomaterials; nanoparticles; nanocarriers; quantum dots; respiratory medicine;

D O I：

10.2174/138945006777435245

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability to incorporate drugs into nanosystems displays a new paradigm in pharmacotherapy that could be used for cell-targeted drug delivery. Nontargeted nanosystems such as nanocarriers that are coated with polymers or albumin and solid lipid particles have been used to transport a large number of compounds. However, nowadays drugs can be coupled to nanocarriers that are specific for cells and/or organs. Thus, drugs that are either trapped within the carriers or deposited in subsurface oil layers could be specifically delivered to organs, tumors and cells. These strategies can be used to concentrate drugs in selected target tissues thus minimizing systemic side effects and toxicity. In addition to these therapeutic options, nanoparticle-based "molecular" imaging displays a field in which this new technology has set the stage for an evolutionary leap in diagnostic imaging. Based on the recent progress in nanobiotechnology, nanoparticles have the potential to become useful tools as therapeutic and diagnostic tools in the near future.

引用

页码：643 / 648

页数：6

共 40 条

[1] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[2] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[3] A universal nucleic acid sequence biosensor with nanomolar detection limits [J].

Baeumner, AJ ;

Pretz, J ;

Fang, S .

ANALYTICAL CHEMISTRY, 2004, 76 (04) :888-894

[4] Particle toxicology: From coal mining to nanotechnology [J].

Borm, PJA .

INHALATION TOXICOLOGY, 2002, 14 (03) :311-324

[5] Nanoparticle and targeted systems for cancer therapy [J].

Brannon-Peppas, L ;

Blanchette, JO .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (11) :1649-1659

[6] Nanostructured hybrid materials from aqueous polymer dispersions [J].

Castelvetro, Valter ;

De Vita, Cinzia .

Advances in Colloid and Interface Science, 2004, 108-109 :167-185

[7] Morphology effects on the optical properties of silver nanoparticles [J].

Chen, SH ;

Webster, S ;

Czerw, R ;

Xu, JF ;

Carroll, DL .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2004, 4 (03) :254-259

[8] Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery [J].

Choi, H ;

Choi, SR ;

Zhou, R ;

Kung, HF ;

Chen, IW .

ACADEMIC RADIOLOGY, 2004, 11 (09) :996-1004

[9] Strong T cell type-1 immune responses to HIV-1 Tat(1-72) protein-coated nanoparticles [J].

Cui, ZR ;

Patel, J ;

Tuzova, M ;

Ray, P ;

Phillips, R ;

Woodward, JG ;

Nath, A ;

Mumper, RJ .

VACCINE, 2004, 22 (20) :2631-2640

[10] Pulmonary surfactant:: functions, abnormalities and therapeutic options [J].

Frerking, I ;

Günther, A ;

Seeger, W ;

Pison, U .

INTENSIVE CARE MEDICINE, 2001, 27 (11) :1699-1717

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