Effects of Activation of Maternal Immune System at Early Stages of Pregnancy on Antitumor Immunity of the Progeny

被引：1
|
作者：
Obernikhin, S. S. [1 ]
机构：
[1] Russian Acad Med Sci, Human Morphol Res Inst, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 156卷 / 01期
关键词：
prenatal exposure; concanavalin A; antitumor immunity; B16; melanoma; ADAPTIVE IMMUNITY; CONCANAVALIN-A; MECHANISMS; HEPATITIS; CANCER; INNATE; CELLS; MICE;
D O I：
10.1007/s10517-013-2279-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of maternal immune system on the formation and functioning of the fetus is an important problem. Single stimulation of immune system of female C57Bl/6 mice with concanavalin A at the early stages of pregnancy before the formation of fetal immune organs was followed by impairment of antitumor immunity in the progeny by the time of puberty. These changes manifested in the increased survival rate of B16 melanoma, high rate of death of tumor-bearing animals, and low cytotoxic activity of spleen cells on L-929 fibrosarcoma cells.
引用
收藏
页码：66 / 69
页数：4
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