Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep

被引：115
作者：
Wu, Joseph C.
Gillin, J. Christian
Buchsbaum, Monte S.
Chen, Phillip
Keator, David B.
Wu, Neetika Khosla
Darnall, Lynn A.
Fallon, James H.
Bunney, William E.
机构：
[1] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA
[2] Univ Calif San Diego, San Diego, CA 92103 USA
[3] Mt Sinai Sch Med, Dept Psychiat, Neurosci PET Lab, New York, NY USA
[4] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA USA
来源：
NEUROPSYCHOPHARMACOLOGY | 2006年 / 31卷 / 12期
关键词：
sleep deprivation; recovery; PET; frontal lobe;
D O I：
10.1038/sj.npp.1301166
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
引用
收藏
页码：2783 / 2792
页数：10
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