Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

被引：215
|
作者：
Kritsanida, M
Mouroutsou, A
Marakos, P
Pouli, N
Papakonstantinou-Garoufalias, S [1 ]
Pannecouque, C
Witvrouw, M
De Clercq, E
机构：
[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
FARMACO | 2002年 / 57卷 / 03期
关键词：
1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles; Schiff base; antiviral activity;
D O I：
10.1016/S0014-827X(01)01189-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：253 / 257
页数：5
相关论文
共 50 条
  • [1] 6-(1-Adamantyl)-3-(2-chlorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
    Tahir, M. Nawaz
    Khan, Mahmood-ul-Hassan
    Hammed, Shahid
    Bokhari, Tanveer Hussain
    Hina, Saira
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1022 - U1800
  • [2] 6-(1-Adamantyl)-3-(2-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
    Khan, Mahmood-ul-Hassan
    Hameed, Shahid
    Tahir, M. Nawaz
    Bokhari, Tanveer Hussain
    Khan, Islam Ullah
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1437 - U3276
  • [3] SYNTHESIS OF SOME 1,2,4-TRIAZOLO [3,4-B][1,3,4]THIADIAZOLES AS POTENTIAL ANTHELMINTICS
    ELKHAWASS, SM
    KHALIL, MA
    HAZZAA, AAB
    BASSIOUNY, HA
    LOUTFY, NF
    FARMACO, 1989, 44 (7-8): : 703 - 709
  • [4] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 1,2,4-TRIAZOLO [3,4-b]-1,3,4-THIADIAZOLES
    Revanasiddappa, B. C.
    Subrahmanyam, E. V. S.
    Satyanarayana, D.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 20 (02) : 195 - 196
  • [5] Antimicrobial and antiinflammatory studies on some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles containing quinoxaline
    Wagle, Shivananda
    Adhikari, Airody Vasudeva
    Kumari, Nalilu Suchetha
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (01) : 629 - 641
  • [6] Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazoles and [1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazines
    Naveena, Channamata Shankara
    Poojary, Boja
    Chandrashekhar, Chikkanna
    Kumari, Nalilu Suchetha
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (02) : 189 - 200
  • [7] Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines
    Khan, Imtiaz
    Zaib, Sumera
    Ibrar, Aliya
    Rama, Nasim Hasan
    Simpson, Jim
    Iqbal, Jamshed
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 78 : 167 - 177
  • [8] Synthesis and antimicrobial activities of some1,2,4-triazolo [3,4-b] [1,3,4] thiadiazoles and 1,2,4-triazolo [3,4-b] [1,3,4] thiadiazines bearing bistrifluoromethylphenyl moiety
    Bobade, V. D., 1600, Journal of Chemical and Pharmaceutical Research (06):
  • [9] Synthesis and antiviral activity of novel [1,2,4]triazolo[3,4b][1,3,4]thiadiazoles, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines
    Farghaly, Abdel-Rahman
    De Clercq, Erik
    El-Kashef, Hussein
    ARKIVOC, 2006, : 137 - 151
  • [10] SYNTHESIS AND FUNGICIDAL ACTIVITIES OF SOME 3-ARYLOXYMETHYL-6-SUBSTITUTED-1,2,4-TRIAZOLO[3,4-B][1,3,4]THIADIAZOLES
    BANO, Q
    TIWARI, N
    GIRI, S
    NIZAMUDDIN
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (03): : 399 - 403
12345