Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

被引：215
作者：
Kritsanida, M
Mouroutsou, A
Marakos, P
Pouli, N
Papakonstantinou-Garoufalias, S [1 ]
Pannecouque, C
Witvrouw, M
De Clercq, E
机构：
[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
FARMACO | 2002年 / 57卷 / 03期
关键词：
1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles; Schiff base; antiviral activity;
D O I：
10.1016/S0014-827X(01)01189-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：253 / 257
页数：5
相关论文
共 12 条
  • [1] ANTIVIRAL AGENTS .2. STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS RELATED TO 1-ADAMANTANAMINE
    ALDRICH, PE
    HERMANN, EC
    MEIER, WE
    PAULSHOCK, M
    PRICHARD, WW
    SYNDER, JA
    WATTS, JC
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (06) : 535 - +
  • [2] COMPARATIVE EFFICACY OF ANTIHERPES DRUGS AGAINST DIFFERENT STRAINS OF HERPES-SIMPLEX VIRUS
    DECLERCQ, E
    DESCAMPS, J
    VERHELST, G
    WALKER, RT
    JONES, AS
    TORRENCE, PF
    SHUGAR, D
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1980, 141 (05) : 563 - 574
  • [3] ANTIVIRAL AND ANTIMETABOLIC ACTIVITIES OF NEPLANOCINS
    DECLERCQ, E
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (01) : 84 - 89
  • [4] Holla BS, 1996, FARMACO, V51, P793
  • [5] INVIDIATA FP, 1991, FARMACO, V46, P1489
  • [6] Invidiata FP, 1996, FARMACO, V51, P659
  • [7] MARAKOS P, 2002, IN PRESS ARZNEIM FOR
  • [8] Pandeya SN, 2000, ARZNEIMITTEL-FORSCH, V50, P55
  • [9] Synthesis and pharmacochemical investigation of some novel 1,2,4-4H-triazoles with potential antiviral activity
    Papakonstantinou-Garoufalia, SS
    Tani, E
    Todoulou, O
    Papadaki-Valiraki, A
    Filippatos, E
    de Clercq, E
    Kourounakis, PN
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1998, 50 (01) : 117 - 124
  • [10] Shi Haijian, 1998, SYNTHETIC COMMUN, V28, P3973
12