Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

被引：216

作者：

Kritsanida, M

Mouroutsou, A

Marakos, P

Pouli, N

Papakonstantinou-Garoufalias, S ^{[1
]}

Pannecouque, C

Witvrouw, M

De Clercq, E

机构：

[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

FARMACO | 2002年 / 57卷 / 03期

关键词：

1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles; Schiff base; antiviral activity;

D O I：

10.1016/S0014-827X(01)01189-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

引用

页码：253 / 257

页数：5

共 12 条

[1] ANTIVIRAL AGENTS .2. STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS RELATED TO 1-ADAMANTANAMINE [J].