Enantioselective synthesis of cyclopropylphosphonates containing quaternary stereocenters using a D2-symmetric chiral catalyst Rh2(S-biTISP)2

被引：45

作者：

Davies, HML ^{[1
]}

Lee, GH ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 13期

关键词：

D O I：

10.1021/ol049525c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rh-2(SbiTISP)(2)-catalyzed reactions of dimethyl aryldiazomethylphosphonates generate donor/acceptor-substituted rhodium carbenoid intermediates capable of cyclopropanation of styrenes in high yields (85-96%), diastereoselectivity (greater than or equal to98% de), and enantioselectivity (76-92% ee).

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页码：2117 / 2120

页数：4

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