SILICA GEL CATALYZED SYNTHESIS OF QUINOXALINE 1,4-DIOXIDES UNDER SOLVENT-FREE CONDITIONS USING MICROWAVE IRRADIATION

被引：5
|
作者：
Sumiyoshi, Yusuke [1 ]
Saito, Hiroaki [1 ]
Miyairi, Shinichi [1 ]
Takabatake, Tohru [1 ]
机构：
[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan
来源：
HETEROCYCLES | 2009年 / 78卷 / 04期
关键词：
Benzofuroxan; Benzofurazan; Dehydration; BENZOFUROXAN; ALUMINA;
D O I：
10.3987/COM-08-11588
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and beta-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.
引用
收藏
页码：905 / 909
页数：5
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